PMID- 11334055
OWN - NLM
STAT- MEDLINE
DCOM- 20010920
LR  - 20191104
IS  - 0897-7194 (Print)
IS  - 0897-7194 (Linking)
VI  - 18
IP  - 3
DP  - 2000
TI  - Neurotrophin and neurotrophin receptor expression in alveolar macrophages: an 
      immunocytochemical study.
PG  - 193-202
AB  - Alveolar macrophages play a crucial role in regulating lung immune responses and 
      in maintaining the integrity of the respiratory tract. Neurotrophins (NTs), 
      besides to their neurotrophic activities, exhibit physiological effects in the 
      immune system. In this study, nerve growth factor (NGF), brain derived 
      neurotrophic factor (BDNF), NT-3 and low- (p75) and high affinity (Trks) NT 
      receptors were investigated by immunocytochemistry in cytospin centrifuged 
      preparations of human alveolar macrophages. Approximately 2.5% alveolar 
      macrophages were immunoreactive for NGF, whereas no macrophages displaying 
      immunoreactivity for BDNF or NT-3 were observed. A 3.5% macrophages displayed 
      immunoreactivity for TrkA-receptor protein, 10% for TrkB-receptor protein (full 
      length isoform), and 2% for TrkC-receptor protein. No low-affinity p75 NT and 
      TrkB[-] truncated isoform receptor immunoreactive macrophages were found. These 
      findings support the hypothesis that NTs and the corresponding receptors may play 
      a role in regulating immunological and functional activity of alveolar 
      macrophages via paracrine/autocrine mechanisms.
FAU - Ricci, A
AU  - Ricci A
AD  - Dipartimento di Scienze Cardiovascolari e Respiratorie, Universita di Roma La 
      Sapienza, Ospedale Carlo Forlanini, Italy. mariotta@axrma.uniroma1.it
FAU - Greco, S
AU  - Greco S
FAU - Mariotta, S
AU  - Mariotta S
FAU - Felici, L
AU  - Felici L
FAU - Amenta, F
AU  - Amenta F
FAU - Bronzetti, E
AU  - Bronzetti E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Growth Factors
JT  - Growth factors (Chur, Switzerland)
JID - 9000468
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neurotrophin 3)
RN  - 0 (Receptor, Nerve Growth Factor)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 9061-61-4 (Nerve Growth Factor)
RN  - EC 2.7.10.1 (Receptor, trkA)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 2.7.10.1 (Receptor, trkC)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - In Vitro Techniques
MH  - Macrophages, Alveolar/immunology/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Nerve Growth Factor/metabolism
MH  - Nerve Growth Factors/*metabolism
MH  - Neurotrophin 3/metabolism
MH  - Receptor, Nerve Growth Factor
MH  - Receptor, trkA/metabolism
MH  - Receptor, trkB/metabolism
MH  - Receptor, trkC/metabolism
MH  - Receptors, Nerve Growth Factor/*metabolism
EDAT- 2001/05/04 10:00
MHDA- 2001/09/21 10:01
CRDT- 2001/05/04 10:00
PHST- 2001/05/04 10:00 [pubmed]
PHST- 2001/09/21 10:01 [medline]
PHST- 2001/05/04 10:00 [entrez]
AID - 10.3109/08977190009003244 [doi]
PST - ppublish
SO  - Growth Factors. 2000;18(3):193-202. doi: 10.3109/08977190009003244.