PMID- 11334611
OWN - NLM
STAT- MEDLINE
DCOM- 20010621
LR  - 20191104
IS  - 0003-3995 (Print)
IS  - 0003-3995 (Linking)
VI  - 44
IP  - 1
DP  - 2001 Jan-Mar
TI  - Complex chromosome abnormality mimicking t(8;21)in an acute myeloblastic 
      leukemia.
PG  - 9-11
AB  - A patient with acute myeloblastic leukemia (AML) and karyotypic abnormality 
      mimicking t(8;21) is reported. Because of the uncommon morphology of blasts for 
      AML with t(8;21), and absence of AML1-ETO fusion in the RT-PCR analysis, 
      fluorescence in situ hybridization (FISH) was applied to precise the abnormality. 
      FISH revealed a complex rearrangement involving chromosomes 7, 21 and 8, and 
      involvement of the AML1 gene without evidence of AML1-ETO fusion. This case of 
      unusual AML illustrates the necessity of collecting all hematologic, cytogenetic, 
      and eventual FISH and RT-PCR data to analyse genetic rearrangements in leukemic 
      patients.
FAU - Busson-Le Coniat, M
AU  - Busson-Le Coniat M
AD  - Unite Inserm U434, SD 401 No 434 CNRS, institut de genetique moleculaire, 27, rue 
      Juliette-Dodu, 75010, Paris, France.
FAU - Daniel, M
AU  - Daniel M
FAU - Berger, R
AU  - Berger R
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Netherlands
TA  - Ann Genet
JT  - Annales de genetique
JID - 0370562
SB  - IM
MH  - Adult
MH  - *Chromosome Aberrations/genetics
MH  - *Chromosome Disorders
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 21
MH  - Chromosomes, Human, Pair 7
MH  - *Chromosomes, Human, Pair 8
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Myeloid, Acute/*genetics
MH  - *Translocation, Genetic
EDAT- 2001/05/04 10:00
MHDA- 2001/06/22 10:01
CRDT- 2001/05/04 10:00
PHST- 2001/05/04 10:00 [pubmed]
PHST- 2001/06/22 10:01 [medline]
PHST- 2001/05/04 10:00 [entrez]
AID - S0003399501010401 [pii]
AID - 10.1016/s0003-3995(01)01040-1 [doi]
PST - ppublish
SO  - Ann Genet. 2001 Jan-Mar;44(1):9-11. doi: 10.1016/s0003-3995(01)01040-1.