PMID- 11334877
OWN - NLM
STAT- MEDLINE
DCOM- 20010927
LR  - 20221207
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 418
IP  - 1-2
DP  - 2001 Apr 20
TI  - Methylenedioxymethamphetamine-induced suppression of interleukin-1beta and tumour 
      necrosis factor-alpha is not mediated by serotonin.
PG  - 147-52
AB  - The purpose of the present study was to examine the role of serotonin release in 
      methylenedioxymethamphetamine (MDMA)-induced immunosuppression in rats. We 
      examined the effect of pretreatment with the selective serotonin reuptake 
      inhibitor paroxetine, and the tryptophan hydroxylase inhibitor 
      para-chlorophenylalanine on MDMA-induced suppression of interleukin-1beta and 
      tumour necrosis factor (TNF)-alpha secretion following an in vivo 
      lipopolysaccharide challenge. Although paroxetine blocked MDMA-induced serotonin 
      depletion in the cortex and hypothalamus, it failed to alter the suppressive 
      effect of MDMA on lipopolysaccharide-induced TNF-alpha secretion. Similarly, 
      although para-chlorophenylalanine caused a 90% depletion in cortical and 
      hypothalamic serotonin content, it failed to alter the suppressive effect of MDMA 
      on lipopolysaccharide-induced interleukin-1beta or TNF-alpha secretion. In 
      conclusion, although MDMA is a potent releaser of serotonin, the suppressive 
      effects of MDMA on lipopolysaccharide-induced proinflammatory cytokine secretion 
      cannot be attributed to its serotonin-releasing properties.
FAU - Connor, T J
AU  - Connor TJ
AD  - Department of Pharmacology, National University of Ireland, Galway, Ireland. 
      thomas.connor@nuigalway.ie
FAU - Dennedy, M C
AU  - Dennedy MC
FAU - Harkin, A
AU  - Harkin A
FAU - Kelly, J P
AU  - Kelly JP
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Interleukin-1)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Serotonin Antagonists)
RN  - 0 (Serotonin Uptake Inhibitors)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 333DO1RDJY (Serotonin)
RN  - 41VRH5220H (Paroxetine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - R5J7E3L9SP (Fenclonine)
SB  - IM
MH  - Animals
MH  - Fenclonine/pharmacology
MH  - Frontal Lobe/*drug effects/metabolism
MH  - Hypothalamus/*drug effects/metabolism
MH  - Immunosuppression Therapy
MH  - Interleukin-1/blood/*metabolism
MH  - Lipopolysaccharides/pharmacology
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/immunology/*pharmacology
MH  - Paroxetine/pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Serotonin/*metabolism
MH  - Serotonin Antagonists/pharmacology
MH  - Selective Serotonin Reuptake Inhibitors/pharmacology
MH  - Tumor Necrosis Factor-alpha/*metabolism
EDAT- 2001/05/04 10:00
MHDA- 2001/09/28 10:01
CRDT- 2001/05/04 10:00
PHST- 2001/05/04 10:00 [pubmed]
PHST- 2001/09/28 10:01 [medline]
PHST- 2001/05/04 10:00 [entrez]
AID - S0014-2999(01)00928-1 [pii]
AID - 10.1016/s0014-2999(01)00928-1 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2001 Apr 20;418(1-2):147-52. doi: 10.1016/s0014-2999(01)00928-1.