PMID- 11336921
OWN - NLM
STAT- MEDLINE
DCOM- 20010712
LR  - 20190906
IS  - 8756-3282 (Print)
IS  - 1873-2763 (Linking)
VI  - 28
IP  - 4
DP  - 2001 Apr
TI  - Gene and protein expression of brain-derived neurotrophic factor and TrkB in bone 
      and cartilage.
PG  - 404-9
AB  - Gene and protein expressions of brain-derived neurotrophic factor (BDNF) and 
      TrkB, the high-affinity receptor of BDNF, were investigated in the femur and 
      mandibular condyle of rats by in situ hybridization and immunohistochemistry. 
      BDNF and TrkB mRNA showed overlapped expression in chondrocytes in proliferating 
      and mature zones of the epiphyseal growth plate cartilage and mandibular condylar 
      cartilage, and in cuboidal-shaped active osteoblasts at the site of endochondral 
      and intramembranous ossification and in trabecular bone. Expression of BDNF 
      protein also showed a similar localization. The present study suggests that BDNF 
      may participate in regulating the development and remodeling of bony tissue in 
      the developing rat.
FAU - Yamashiro, T
AU  - Yamashiro T
AD  - Department of Orthodontics, Okayama University Dental School, Okayama, Japan.
FAU - Fukunaga, T
AU  - Fukunaga T
FAU - Yamashita, K
AU  - Yamashita K
FAU - Kobashi, N
AU  - Kobashi N
FAU - Takano-Yamamoto, T
AU  - Takano-Yamamoto T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Bone
JT  - Bone
JID - 8504048
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (DNA Primers)
RN  - 0 (RNA, Messenger)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Cartilage/*metabolism
MH  - DNA Primers
MH  - Immunohistochemistry
MH  - In Situ Hybridization
MH  - Male
MH  - Mandible/*metabolism
MH  - RNA, Messenger/genetics/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Receptor, trkB/genetics/*metabolism
EDAT- 2001/05/05 10:00
MHDA- 2001/07/13 10:01
CRDT- 2001/05/05 10:00
PHST- 2001/05/05 10:00 [pubmed]
PHST- 2001/07/13 10:01 [medline]
PHST- 2001/05/05 10:00 [entrez]
AID - S8756-3282(01)00405-7 [pii]
AID - 10.1016/s8756-3282(01)00405-7 [doi]
PST - ppublish
SO  - Bone. 2001 Apr;28(4):404-9. doi: 10.1016/s8756-3282(01)00405-7.