PMID- 11337297 OWN - NLM STAT- MEDLINE DCOM- 20010607 LR - 20190714 IS - 1527-9995 (Electronic) IS - 0090-4295 (Linking) VI - 57 IP - 5 DP - 2001 May TI - Are serum hormones associated with the risk of prostate cancer? Prospective results from the Massachusetts Male Aging Study. PG - 930-5 AB - OBJECTIVES: To determine whether prediagnostic serum hormones are predictive of prostate cancer risk in a sample of men 40 to 70 years old at baseline. METHODS: Seventeen serum hormones, including androgens, estrogens, and adrenal and pituitary hormones, were measured at baseline (1987 to 1989) and used to predict incident prostate cancer by follow-up (1995 to 1997) using data from the Massachusetts Male Aging Study, a prospective, population-based random sample. RESULTS: Seventy men (4%) of 1576 were diagnosed with prostate cancer between the baseline and follow-up periods (approximately 8 years). None of the hormones were associated with prostate cancer risk except for androstanediol glucuronide (AAG), which exhibited a nonlinear, inverse relationship with prostate cancer (P <0.003) when age, body mass index, alcohol use, dihydrotestosterone, and total prostate-specific antigen were controlled for. Men in the second, third, and fourth quartiles of AAG relative to the first were less likely to be diagnosed with prostate cancer, although only the comparison of the second versus the first achieved statistical significance (odds ratio 0.2, 99% confidence interval 0.04 to 0.6). No dose-response relationships were observed. CONCLUSIONS: The lack of association with most hormones and the nonlinear association with AAG calls into question whether serum hormones collected during midlife are risk factors for prostate cancer. FAU - Mohr, B A AU - Mohr BA AD - New England Research Institutes, Watertown, Massachusetts, USA. FAU - Feldman, H A AU - Feldman HA FAU - Kalish, L A AU - Kalish LA FAU - Longcope, C AU - Longcope C FAU - McKinlay, J B AU - McKinlay JB LA - eng GR - AG-04673/AG/NIA NIH HHS/United States GR - DK-44995/DK/NIDDK NIH HHS/United States PT - Comparative Study PT - Journal Article PT - Research Support, U.S. Gov't, P.H.S. PL - United States TA - Urology JT - Urology JID - 0366151 RN - 0 (Adrenal Cortex Hormones) RN - 0 (Androgens) RN - 0 (Estrogens) RN - 0 (Pituitary Hormones) RN - 25126-76-5 (Androstane-3,17-diol) RN - 27195-25-1 (androstane-3,17-diol glucuronide) RN - EC 3.4.21.77 (Prostate-Specific Antigen) SB - IM MH - Adrenal Cortex Hormones/blood MH - Adult MH - Aged MH - Androgens/*blood MH - Androstane-3,17-diol/analogs & derivatives/*blood MH - Estrogens/blood MH - Follow-Up Studies MH - Humans MH - Male MH - Massachusetts/epidemiology MH - Middle Aged MH - Pituitary Hormones/blood MH - Prospective Studies MH - Prostate-Specific Antigen/blood MH - Prostatic Neoplasms/*blood/epidemiology MH - Risk Factors MH - Sampling Studies EDAT- 2001/05/19 10:00 MHDA- 2001/06/08 10:01 CRDT- 2001/05/19 10:00 PHST- 2001/05/19 10:00 [pubmed] PHST- 2001/06/08 10:01 [medline] PHST- 2001/05/19 10:00 [entrez] AID - S0090-4295(00)01116-X [pii] AID - 10.1016/s0090-4295(00)01116-x [doi] PST - ppublish SO - Urology. 2001 May;57(5):930-5. doi: 10.1016/s0090-4295(00)01116-x.