PMID- 11338187
OWN - NLM
STAT- MEDLINE
DCOM- 20010913
LR  - 20190718
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 12
IP  - 6
DP  - 2001 May 8
TI  - Dopamine regulates brain-derived neurotrophic factor (BDNF) expression in 
      cultured embryonic mouse striatal cells.
PG  - 1175-9
AB  - The differentiation of striatal GABAergic neurons coincides with the perinatal 
      establishment of nigrostriatal dopaminergic synaptic connections. We have shown 
      previously that dopamine stimulates the maturation of striatal GABAergic neurons. 
      Since BDNF also regulates the development of GABAergic cells, we hypothesized 
      that dopamine might affect striatal BDNF expression. The influence of dopamine on 
      BDNF protein/mRNA and trkB mRNA levels was studied in neuronal and astroglia 
      cultures of the mouse striatum. Stimulation with dopamine and a dopamine D1 
      receptor agonist increased BDNF mRNA and protein but not trkB mRNA in neuronal 
      cultures. Our data indicate a potential role for dopamine in the developmental 
      regulation of striatal BDNF expression and suggest that dopamine effects on 
      GABAergic cells may be intertwined with BDNF action.
FAU - Kuppers, E
AU  - Kuppers E
AD  - Abteilung Anatomie und Zellbiologie, Universitat Ulm, 89069 Ulm, Germany.
FAU - Beyer, C
AU  - Beyer C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cardiotonic Agents)
RN  - 0 (Dopamine Agonists)
RN  - 0 (Receptors, Dopamine D1)
RN  - 67287-49-4 (2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine/pharmacology
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis/metabolism
MH  - Cardiotonic Agents/*pharmacology
MH  - Cells, Cultured
MH  - Corpus Striatum/*drug effects/growth & development/metabolism
MH  - Dopamine/*pharmacology
MH  - Dopamine Agonists/pharmacology
MH  - Embryo, Mammalian
MH  - Female
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Receptor, trkB/metabolism
MH  - Receptors, Dopamine D1/agonists/metabolism
EDAT- 2001/05/08 10:00
MHDA- 2001/09/14 10:01
CRDT- 2001/05/08 10:00
PHST- 2001/05/08 10:00 [pubmed]
PHST- 2001/09/14 10:01 [medline]
PHST- 2001/05/08 10:00 [entrez]
AID - 10.1097/00001756-200105080-00025 [doi]
PST - ppublish
SO  - Neuroreport. 2001 May 8;12(6):1175-9. doi: 10.1097/00001756-200105080-00025.