PMID- 11338197
OWN - NLM
STAT- MEDLINE
DCOM- 20010913
LR  - 20190718
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 12
IP  - 6
DP  - 2001 May 8
TI  - Performance-enhancing effects of CRF-BP ligand inhibitors.
PG  - 1231-4
AB  - Intracerebroventricular (i.c.v.) administration of corticotropin-releasing factor 
      (CRF) peptide fragments with low affinity for CRF receptors reportedly improves 
      cognitive performance without producing anxiety. These compounds are hypothesized 
      to act by displacing endogenous peptide from the CRF-binding protein (CRF-BP). To 
      test this hypothesis, the present study determined whether the 
      performance-enhancing potency of CRF fragments was related to their affinity for 
      the CRF-BP. Rank ordering of the optimal doses of these compounds for 
      facilitating spatial navigation corresponded to their affinity for the CRF-BP. 
      i.c.v. pretreatment with performance-enhancing doses of r/h CRF(1-41)-OH (5 
      micrograms) or r/h CRF(6-33) (25 micrograms) did not increase emotionality. These 
      findings replicate the dissociability of the cognition- and anxiety-related 
      effects of CRF-related compounds and suggest that CRF fragments facilitate 
      performance via the CRF-BP.
FAU - Zorrilla, E P
AU  - Zorrilla EP
AD  - Neurocrine Biosciences, Inc., 10550 N. Torrey Pines Rd, La Jolla, CA 92037, USA.
FAU - Schulteis, G
AU  - Schulteis G
FAU - Ling, N
AU  - Ling N
FAU - Koob, G F
AU  - Koob GF
FAU - De Souza, E B
AU  - De Souza EB
LA  - eng
GR  - 2R44-NS33426/NS/NINDS NIH HHS/United States
GR  - 5T32-MH19185-7/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Carrier Proteins)
RN  - 0 (Ligands)
RN  - 134773-81-2 (corticotropin releasing factor-binding protein)
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
SB  - IM
MH  - Animals
MH  - Carrier Proteins/*antagonists & inhibitors/*metabolism
MH  - Corticotropin-Releasing Hormone/metabolism/*pharmacology
MH  - Emotions/*drug effects/physiology
MH  - Ligands
MH  - Male
MH  - Maze Learning/*drug effects/physiology
MH  - Motor Activity/*drug effects/physiology
MH  - Rats
MH  - Rats, Wistar
EDAT- 2001/05/08 10:00
MHDA- 2001/09/14 10:01
CRDT- 2001/05/08 10:00
PHST- 2001/05/08 10:00 [pubmed]
PHST- 2001/09/14 10:01 [medline]
PHST- 2001/05/08 10:00 [entrez]
AID - 10.1097/00001756-200105080-00035 [doi]
PST - ppublish
SO  - Neuroreport. 2001 May 8;12(6):1231-4. doi: 10.1097/00001756-200105080-00035.