PMID- 11338283
OWN - NLM
STAT- MEDLINE
DCOM- 20010913
LR  - 20220409
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 12
IP  - 2
DP  - 2001 Apr
TI  - The prevalence of atopic disorders in children with chronic otitis media with 
      effusion.
PG  - 102-6
AB  - We studied 209 children, referred to a multi-disciplinary 'Glue ear/Allergy' 
      clinic at our hospital with a history of chronic or recurrent otitis media with 
      effusion (OME), in order to determine the prevalence of atopic disease in this 
      population. Referrals were made either from within the hospital by Ear, Nose and 
      Throat (ENT) Surgeons and Audiological Physicians (internal), or by General 
      Practitioners (external). Assessment of atopic status was based on medical 
      history, physical examination, nasal smears and skin-prick testing (SPT) in all 
      children; and on blood eosinophil counts and total immunoglobulin E (IgE) levels 
      in a randomly selected subset. The main outcome measures were number of children 
      with rhinitis, asthma, eczema, positive SPT, raised IgE level (> 100 IU/l), and 
      nasal and blood eosinophilia. We found allergic rhinitis in 89%, asthma in 36%, 
      and eczema in 24%. SPTs were positive to one or more of eight common inhalant 
      aeroallergens in 57% of children. Blood tests in the selected subset revealed 
      eosinophilia in 40% and a raised serum IgE in 28%. The worldwide prevalence of 
      allergic rhinitis in children has been estimated to be 20%. The 89% prevalence 
      found in this study is very high and there are a number of reasons which suggest 
      that there may be a causal relationship. Whole-population studies will be 
      required to confirm these findings, which could have important therapeutic 
      implications for OME.
FAU - Alles, R
AU  - Alles R
AD  - Glue Ear Clinic, Royal National Throat, Nose and Ear Hospital, Gray's Inn Road, 
      London, UK.
FAU - Parikh, A
AU  - Parikh A
FAU - Hawk, L
AU  - Hawk L
FAU - Darby, Y
AU  - Darby Y
FAU - Romero, J N
AU  - Romero JN
FAU - Scadding, G
AU  - Scadding G
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Allergens)
SB  - IM
MH  - Allergens/immunology
MH  - Asthma/epidemiology/immunology
MH  - Child
MH  - Child, Preschool
MH  - Chronic Disease
MH  - Eczema/epidemiology/immunology
MH  - Female
MH  - Humans
MH  - Hypersensitivity, Immediate/*complications/epidemiology/immunology
MH  - Male
MH  - Otitis Media with Effusion/*complications
MH  - Prevalence
MH  - Random Allocation
MH  - Rhinitis, Allergic, Perennial/epidemiology/immunology
MH  - Rhinitis, Allergic, Seasonal/epidemiology/immunology
MH  - Skin Tests
EDAT- 2001/05/08 10:00
MHDA- 2001/09/14 10:01
CRDT- 2001/05/08 10:00
PHST- 2001/05/08 10:00 [pubmed]
PHST- 2001/09/14 10:01 [medline]
PHST- 2001/05/08 10:00 [entrez]
AID - 10.1046/j.0905-6157.2000.00008.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2001 Apr;12(2):102-6. doi: 
      10.1046/j.0905-6157.2000.00008.x.