PMID- 11339845
OWN - NLM
STAT- MEDLINE
DCOM- 20010719
LR  - 20041117
IS  - 0306-9877 (Print)
IS  - 0306-9877 (Linking)
VI  - 56
IP  - 4
DP  - 2001 Apr
TI  - Redefining 'self': the role of microflora (commensals) mismatch in the 
      development of GvHD after allogeneic stem cell transplantation and some possible 
      remedies.
PG  - 448-50
AB  - The discovery of human leukocyte antigen (HLA) molecules and their role in 
      allorecognition has facilitated the initiation of allogeneic stem cell 
      transplantation in human beings. HLA mismatch to a large extent explains the 
      phenomenon of graft rejection and graft versus host disease (GvHD). Incidence of 
      GvHD even in syngeneic transplants suggests a role for extra genetic factors in 
      the causation of GvHD. We hereby propose a hypothesis that the definition of 
      'self' (in the immunological sense) should be broadened to include both 
      genetically determined molecules (e.g. HLA) and the microbial flora that colonize 
      an individual. This hypothesis explains several observations about GvHD which can 
      not fully be accounted for by the HLA mismatch theory and gives some clues 
      towards circumventing GvHD.
CI  - Copyright 2001 Harcourt Publishers Ltd.
FAU - Singh, H P
AU  - Singh HP
AD  - Department of Medical Oncology, Institute Rotary Cancer Hospital, All India 
      Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
FAU - Gupta, S
AU  - Gupta S
FAU - Raju, G M
AU  - Raju GM
FAU - Kochupillai, V
AU  - Kochupillai V
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Med Hypotheses
JT  - Medical hypotheses
JID - 7505668
SB  - IM
MH  - Age Factors
MH  - Graft vs Host Disease/immunology/*microbiology
MH  - Hematopoietic Stem Cell Transplantation/*adverse effects
MH  - Humans
MH  - Transplantation, Homologous
EDAT- 2001/05/08 10:00
MHDA- 2001/07/20 10:01
CRDT- 2001/05/08 10:00
PHST- 2001/05/08 10:00 [pubmed]
PHST- 2001/07/20 10:01 [medline]
PHST- 2001/05/08 10:00 [entrez]
AID - S0306-9877(00)91197-6 [pii]
AID - 10.1054/mehy.2000.1197 [doi]
PST - ppublish
SO  - Med Hypotheses. 2001 Apr;56(4):448-50. doi: 10.1054/mehy.2000.1197.