PMID- 11340117
OWN - NLM
STAT- MEDLINE
DCOM- 20010607
LR  - 20180330
IS  - 0022-3166 (Print)
IS  - 0022-3166 (Linking)
VI  - 131
IP  - 5
DP  - 2001 May
TI  - Dietary trans fatty acids combined with a marginal essential fatty acid status 
      during the pre- and postnatal periods do not affect growth or brain fatty acids 
      but may alter behavioral development in B6D2F(2) mice.
PG  - 1568-73
AB  - The objective of this study was to investigate whether dietary trans fatty acids 
      (TFA) during the pre- and postnatal periods would exacerbate the effects of 
      marginal essential fatty acid (EFA) status on growth, brain long-chain 
      polyunsaturated fatty acids (LC-PUFA) and behavioral development in B6D2F(2) 
      mice. Pregnant B6D2F(1) females were randomly assigned to one of the following 
      three diets: marginal EFA plus 22% trans 18:1 (mEFA + TFA); marginal EFA (mEFA); 
      and control (CON). The total 18:1 content in all diets was similar. The offspring 
      were weaned and maintained on the same diets. Both the mEFA and mEFA + TFA groups 
      had reduced growth and brain weight compared with CON, but did not differ from 
      one another. As expected, the mEFA and mEFA + TFA groups had reduced 
      docosahexaenoic acid [DHA; 22:6(n-3)]) and increased 22:5(n-6) concentrations in 
      brain phosphatidylcholine (PC) and phosphatidylethanolamine (PE) compared with 
      the CON group, but again did not differ from one another. Reversal learning in 
      the T-water maze was significantly slower in the mEFA + TFA groups compared with 
      the mEFA group and both were slower than the CON group. These findings illustrate 
      that TFA combined with a marginal EFA status do not exacerbate the effects of 
      marginal EFA status on growth or brain LC-PUFA. However, long-term effects of 
      dietary TFA during the pre- and postnatal period on behavioral development and 
      neural function should be investigated in future studies.
FAU - Wauben, I P
AU  - Wauben IP
AD  - Department of Health Studies and Gerontology, University of Waterloo, Waterloo, 
      Canada N2L 3G1.
FAU - Xing, H C
AU  - Xing HC
FAU - McCutcheon, D
AU  - McCutcheon D
FAU - Wainwright, P E
AU  - Wainwright PE
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 0 (Fatty Acids, Essential)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Behavior, Animal/*drug effects
MH  - Body Weight
MH  - Brain/*drug effects/growth & development
MH  - Diet
MH  - Embryonic and Fetal Development/*drug effects
MH  - Fatty Acids, Essential/*pharmacology
MH  - Female
MH  - Male
MH  - Maternal-Fetal Exchange
MH  - Mice
MH  - Organ Size
MH  - Pregnancy
EDAT- 2001/05/08 10:00
MHDA- 2001/06/08 10:01
CRDT- 2001/05/08 10:00
PHST- 2001/05/08 10:00 [pubmed]
PHST- 2001/06/08 10:01 [medline]
PHST- 2001/05/08 10:00 [entrez]
AID - 10.1093/jn/131.5.1568 [doi]
PST - ppublish
SO  - J Nutr. 2001 May;131(5):1568-73. doi: 10.1093/jn/131.5.1568.