PMID- 11340642
OWN - NLM
STAT- MEDLINE
DCOM- 20010719
LR  - 20131121
IS  - 0360-4012 (Print)
IS  - 0360-4012 (Linking)
VI  - 64
IP  - 4
DP  - 2001 May 15
TI  - BDNF dependence in neuroblastoma.
PG  - 355-63
AB  - Neuroblastomas are heterogeneous tumors arising from sympathetic precursors in 
      the neural crest. Growth factor stimulation of neuroblastomas promote diverse 
      biological responses (mitogenesis, differentiation, cell death) depending on the 
      particular tumor studied. Here we show that brief treatment with retinoic acid 
      (RA) rendered the human neuroblastoma lines SY5Y, NGP, SMS-KCNR, and SK-N-SH 
      dependent on brain-derived neurotrophic factor (BDNF) for survival. The BDNF- and 
      trkB-expressing line SMS-KCN was dependent on an autocrine BDNF/trkB survival 
      without exposure to RA. We conclude that the BDNF/trkB pathway plays an important 
      role in neuroblastoma survival and speculate on a possible role in tumor 
      pathogenesis.
CI  - Copyright 2001 Wiley-Liss, Inc.
FAU - Feng, X
AU  - Feng X
AD  - Department of Neurology, University of Chicago, Chicago, Illinois, USA.
FAU - Jiang, H
AU  - Jiang H
FAU - Baik, J C
AU  - Baik JC
FAU - Edgar, C
AU  - Edgar C
FAU - Eide, F F
AU  - Eide FF
LA  - eng
GR  - 5K12AG00488/AG/NIA NIH HHS/United States
GR  - K11AG99568/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurosci Res
JT  - Journal of neuroscience research
JID - 7600111
RN  - 0 (Antibodies)
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 5688UTC01R (Tretinoin)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Antibodies/pharmacology
MH  - Antineoplastic Agents/pharmacology
MH  - Apoptosis/drug effects/*physiology
MH  - Brain-Derived Neurotrophic Factor/drug effects/immunology/*metabolism
MH  - Dose-Response Relationship, Drug
MH  - Humans
MH  - In Situ Nick-End Labeling
MH  - Mutation/drug effects/*physiology
MH  - Neuroblastoma/*metabolism/pathology
MH  - Receptor, trkB/drug effects/*metabolism
MH  - Tretinoin/pharmacology
MH  - Tumor Cells, Cultured/drug effects
EDAT- 2001/05/08 10:00
MHDA- 2001/07/20 10:01
CRDT- 2001/05/08 10:00
PHST- 2001/05/08 10:00 [pubmed]
PHST- 2001/07/20 10:01 [medline]
PHST- 2001/05/08 10:00 [entrez]
AID - 10.1002/jnr.1086 [doi]
PST - ppublish
SO  - J Neurosci Res. 2001 May 15;64(4):355-63. doi: 10.1002/jnr.1086.