PMID- 11342445
OWN - NLM
STAT- MEDLINE
DCOM- 20010614
LR  - 20210216
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 97
IP  - 10
DP  - 2001 May 15
TI  - Impaired dendritic cell maturation in patients with chronic, but not resolved, 
      hepatitis C virus infection.
PG  - 3171-6
AB  - Dendritic cells (DCs) are important for the initiation of immune responses to 
      foreign antigens. Their antigen uptake and presentation capacities enable them to 
      prime and activate T cells. Immature DCs capture antigens; however, they must be 
      activated to mature before serving as efficient antigen-presenting cells. The 
      antigen-presenting capacity of DCs can be diminished during viral infection and 
      as a consequence of tumor formation. Chronic infection with hepatitis C virus 
      (HCV) has been shown to affect the allostimulatory function of DCs. In this 
      study, it is demonstrated that monocyte-derived DCs from patients with chronic 
      HCV infection do not respond to maturation stimuli. Instead, they maintain their 
      immature phenotype, reflected by the pattern of cell surface markers and by their 
      continued capacity to uptake antigen. Moreover, their allostimulatory abilities 
      are impaired compared with those of mature DCs derived from healthy donors. To 
      investigate a possible correlation between viral clearance and this DC maturation 
      defect, patients with resolved HCV infection after a course of antiviral therapy 
      were studied. Results demonstrate that DCs from patients who cleared HCV behaved 
      like DCs from healthy donors: in response to maturation stimuli, they decrease 
      antigen uptake, up-regulate expression of appropriate surface markers, and are 
      potent stimulators of allogeneic T cells. (Blood. 2001;97:3171-3176)
FAU - Auffermann-Gretzinger, S
AU  - Auffermann-Gretzinger S
AD  - Divisions of Oncology and of Gastroenterology and Hepatology, Department of 
      Medicine, Stanford University Medical Center, Stanford, CA 94305-5151, USA.
FAU - Keeffe, E B
AU  - Keeffe EB
FAU - Levy, S
AU  - Levy S
LA  - eng
GR  - CA34233/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Lipopolysaccharide Receptors)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Antigen Presentation
MH  - Dendritic Cells/*physiology
MH  - Female
MH  - Hepatitis C, Chronic/*immunology
MH  - Histocompatibility Antigens Class II/analysis
MH  - Humans
MH  - Leukocytes, Mononuclear/immunology
MH  - Lipopolysaccharide Receptors/analysis
MH  - Lymphocyte Culture Test, Mixed
MH  - Male
MH  - Middle Aged
MH  - Tumor Necrosis Factor-alpha/pharmacology
EDAT- 2001/05/09 10:00
MHDA- 2001/06/15 10:01
CRDT- 2001/05/09 10:00
PHST- 2001/05/09 10:00 [pubmed]
PHST- 2001/06/15 10:01 [medline]
PHST- 2001/05/09 10:00 [entrez]
AID - S0006-4971(20)55639-5 [pii]
AID - 10.1182/blood.v97.10.3171 [doi]
PST - ppublish
SO  - Blood. 2001 May 15;97(10):3171-6. doi: 10.1182/blood.v97.10.3171.