PMID- 11343646
OWN - NLM
STAT- MEDLINE
DCOM- 20010531
LR  - 20220309
IS  - 0896-6273 (Print)
IS  - 0896-6273 (Linking)
VI  - 30
IP  - 1
DP  - 2001 Apr
TI  - Hepatocyte growth factor/scatter factor is a motogen for interneurons migrating 
      from the ventral to dorsal telencephalon.
PG  - 79-89
AB  - Cortical interneurons arise from the proliferative zone of the ventral 
      telencephalon, the ganglionic eminence, and migrate into the developing 
      neocortex. The spatial patterns of migratory interneurons reflect the 
      complementary expression of hepatocyte growth factor/scatter factor (HGF/SF) and 
      its receptor, MET, in the forebrain. Scatter assays on forebrain explants 
      demonstrate regionally specific motogenic activity due to HGF/SF. In addition, 
      exogenous ligand disrupts normal cell migration. Mice lacking the urokinase-type 
      plasminogen activator receptor (u-PAR), a key component of HGF/SF activation, 
      exhibit deficient scatter activity in the forebrain, abnormal interneuron 
      migration from the ganglionic eminence, and reduced interneurons in the frontal 
      and parietal cortex. The data suggest that HGF/SF motogenic activity, which is 
      essential for normal development of other organ systems, is a conserved mechanism 
      that regulates trans-telencephalic migration of interneurons.
FAU - Powell, E M
AU  - Powell EM
AD  - Department of Neurobiology, University of Pittsburgh School of Medicine, 
      Pittsburgh, PA 15261, USA. epowell+@pitt.edu
FAU - Mars, W M
AU  - Mars WM
FAU - Levitt, P
AU  - Levitt P
LA  - eng
GR  - MH12651/MH/NIMH NIH HHS/United States
GR  - MH45507/MH/NIMH NIH HHS/United States
GR  - NS07391/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - 0 (Calbindins)
RN  - 0 (S100 Calcium Binding Protein G)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - EC 2.7.10.1 (Proto-Oncogene Proteins c-met)
SB  - IM
MH  - Animals
MH  - Body Patterning/drug effects/genetics
MH  - Calbindins
MH  - Cell Differentiation/drug effects/genetics
MH  - Cell Movement/drug effects/*genetics
MH  - Cells, Cultured/cytology/drug effects/metabolism
MH  - Cerebral Cortex/cytology/embryology/metabolism
MH  - Fetus
MH  - Gene Expression Regulation, Developmental/drug effects/physiology
MH  - Hepatocyte Growth Factor/genetics/*metabolism/pharmacology
MH  - Immunohistochemistry
MH  - Interneurons/cytology/drug effects/*metabolism
MH  - Mice
MH  - Mice, Knockout/abnormalities/metabolism
MH  - Proto-Oncogene Proteins c-met/genetics/metabolism
MH  - S100 Calcium Binding Protein G/metabolism
MH  - Signal Transduction/drug effects/genetics
MH  - Telencephalon/cytology/*embryology/metabolism
EDAT- 2001/05/10 10:00
MHDA- 2001/06/02 10:01
CRDT- 2001/05/10 10:00
PHST- 2001/05/10 10:00 [pubmed]
PHST- 2001/06/02 10:01 [medline]
PHST- 2001/05/10 10:00 [entrez]
AID - S0896-6273(01)00264-1 [pii]
AID - 10.1016/s0896-6273(01)00264-1 [doi]
PST - ppublish
SO  - Neuron. 2001 Apr;30(1):79-89. doi: 10.1016/s0896-6273(01)00264-1.