PMID- 11343691
OWN - NLM
STAT- MEDLINE
DCOM- 20010705
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 418
IP  - 3
DP  - 2001 Apr 27
TI  - Intravenous administration of ecstasy (3,4-methylendioxymethamphetamine) enhances 
      cortical and striatal acetylcholine release in vivo.
PG  - 207-11
AB  - The effect of intravenous administration of 3,4-methylendioxymethamphetamine 
      (MDMA), in a range of doses (0.32-3.2 mg/kg) that have been shown to maintain 
      self-administration behaviour in rats, on in vivo acetylcholine release from rat 
      prefrontal cortex and dorsal striatum was studied by means of microdialysis with 
      vertical concentric probes. Intravenous administration of MDMA dose-dependently 
      increased basal acetylcholine release from the prefrontal cortex to 57+/-21%, 
      98+/-20%, 102+/-7% and 141+/-14% above baseline, at doses of 0.32, 0.64, 1.0 and 
      3.2 mg/kg, respectively. MDMA also stimulated striatal acetylcholine release at 
      the dose of 3.2 mg/kg i.v. (the maximal increase being 32+/-3% above baseline) 
      while at the dose of 1 mg/kg i.v., MDMA failed to affect basal acetylcholine 
      output. Administration of MDMA also dose-dependently stimulated behaviour. The 
      results of the present study show that MDMA affects measures of central 
      cholinergic neurotransmission in vivo and suggest that at least some of the 
      psychomotor stimulant actions of MDMA might be positively coupled with an 
      increase in prefrontal cortical and striatal acetylcholine release.
FAU - Acquas, E
AU  - Acquas E
AD  - Department of Toxicology, University of Cagliari, V.le A Diaz, 182, I-09126, 
      Cagliari, Italy. acquas@unica.it
FAU - Marrocu, P
AU  - Marrocu P
FAU - Pisanu, A
AU  - Pisanu A
FAU - Cadoni, C
AU  - Cadoni C
FAU - Zernig, G
AU  - Zernig G
FAU - Saria, A
AU  - Saria A
FAU - Di Chiara, G
AU  - Di Chiara G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - N9YNS0M02X (Acetylcholine)
SB  - IM
MH  - Acetylcholine/*metabolism
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Cerebral Cortex/*drug effects/metabolism
MH  - Corpus Striatum/*drug effects/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Injections, Intravenous
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Time Factors
EDAT- 2001/05/10 10:00
MHDA- 2001/07/06 10:01
CRDT- 2001/05/10 10:00
PHST- 2001/05/10 10:00 [pubmed]
PHST- 2001/07/06 10:01 [medline]
PHST- 2001/05/10 10:00 [entrez]
AID - S0014299901009372 [pii]
AID - 10.1016/s0014-2999(01)00937-2 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2001 Apr 27;418(3):207-11. doi: 10.1016/s0014-2999(01)00937-2.