PMID- 11343780
OWN - NLM
STAT- MEDLINE
DCOM- 20010614
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 126
IP  - 1
DP  - 2001 Apr 1
TI  - No increased frequency of trisomies 8 and 9 by fluorescence in situ hybridization 
      in untreated patients with essential thrombocythemia.
PG  - 56-9
AB  - Essential thrombocythemia (ET) is one of the diseases included among the 
      myeloproliferative disorders in which trisomies for chromosomes 8 and 9 commonly 
      occur. In ET, only a few patients are known to show clonal abnormalities. With 
      fluorescence in situ hybridization (FISH), interphase cells can be evaluated and 
      clones can be detected even though not revealed by conventional cytogenetic 
      methods. By using FISH for enumeration of chromosomes 8 and 9 in bone marrow 
      cells, we studied 22 patients with ET; 20 of them were investigated at the time 
      of diagnosis when they were still untreated with myelosuppressive agents. Only 
      two patients had trisomy 8; one of them was also found to have +8 with 
      conventional cytogenetics. None of the patients had trisomy 9; two patients had 
      borderline values in comparison to a control group. Thus, in ET, no increased 
      frequency of patients with trisomy for 8 or 9 at the time of diagnosis could be 
      detected with FISH.
FAU - Swolin, B
AU  - Swolin B
AD  - Department of Clinical Chemistry, Sahlgrenska University Hospital, Goteborg 
      University, 413 45, Goteborg, SE, Sweden.
FAU - Safai-Kutti, S
AU  - Safai-Kutti S
FAU - Anghem, E
AU  - Anghem E
FAU - Kutti, J
AU  - Kutti J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - *Chromosomes, Human, Pair 8
MH  - *Chromosomes, Human, Pair 9
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Thrombocytopenia/*genetics
MH  - *Trisomy
EDAT- 2001/05/10 10:00
MHDA- 2001/06/15 10:01
CRDT- 2001/05/10 10:00
PHST- 2001/05/10 10:00 [pubmed]
PHST- 2001/06/15 10:01 [medline]
PHST- 2001/05/10 10:00 [entrez]
AID - S0165-4608(00)00389-7 [pii]
AID - 10.1016/s0165-4608(00)00389-7 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2001 Apr 1;126(1):56-9. doi: 
      10.1016/s0165-4608(00)00389-7.