PMID- 11343865
OWN - NLM
STAT- MEDLINE
DCOM- 20010809
LR  - 20190915
IS  - 0920-9964 (Print)
IS  - 0920-9964 (Linking)
VI  - 49
IP  - 1-2
DP  - 2001 Apr 15
TI  - Association study of schizophrenia with polymorphisms at six candidate genes.
PG  - 65-71
AB  - Clinical studies have shown that there is a genetic contribution to the 
      pathogenesis of schizophrenia. The molecular mechanisms of effective 
      antipsychotic drugs and recent advances in neural development suggest that 
      several dopamine receptor, serotonin receptor and neurotrophic factor genes might 
      be involved in the disorder. In this study, we assessed the associations between 
      schizophrenia and polymorphisms in the D2 and D3 dopamine receptor (DRD2, DRD3), 
      the serotonin 2A receptor (5HTR2A), the brain-derived neurotrophic factor (BDNF), 
      the ciliary neurotrophic factor (CNTF) and the neurotrophin-3 (NT-3) genes. Our 
      results suggest that the polymorphisms at the DRD3, 5HTR2A, CNTF and BDNF gene 
      loci are unlikely to make our sample more genetically susceptible to 
      schizophrenia. However, we found significant differences in microsatellite allele 
      frequencies between schizophrenic and control groups for DRD2 in the whole sample 
      and for DRD2 and NT-3 only in women. Therefore, clinical differences in the 
      presentation of schizophrenia between gender might be related to genetic factors.
FAU - Virgos, C
AU  - Virgos C
AD  - Hospital Psiquiatric Universitari Institut Pere Mata, Ctra. de l'Institut Pere 
      Mata, s/n. 43206, Reus, Spain.
FAU - Martorell, L
AU  - Martorell L
FAU - Valero, J
AU  - Valero J
FAU - Figuera, L
AU  - Figuera L
FAU - Civeira, F
AU  - Civeira F
FAU - Joven, J
AU  - Joven J
FAU - Labad, A
AU  - Labad A
FAU - Vilella, E
AU  - Vilella E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (DRD3 protein, human)
RN  - 0 (Genetic Markers)
RN  - 0 (Receptor, Serotonin, 5-HT2A)
RN  - 0 (Receptors, Dopamine D2)
RN  - 0 (Receptors, Dopamine D3)
RN  - 0 (Receptors, Serotonin)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/genetics
MH  - Female
MH  - Gene Frequency/genetics
MH  - Genetic Markers
MH  - Humans
MH  - Male
MH  - Polymorphism, Genetic/*genetics
MH  - Receptor, Serotonin, 5-HT2A
MH  - Receptors, Dopamine D2/genetics
MH  - Receptors, Dopamine D3
MH  - Receptors, Serotonin/genetics
MH  - Schizophrenia/*genetics
EDAT- 2001/05/10 10:00
MHDA- 2001/08/10 10:01
CRDT- 2001/05/10 10:00
PHST- 2001/05/10 10:00 [pubmed]
PHST- 2001/08/10 10:01 [medline]
PHST- 2001/05/10 10:00 [entrez]
AID - S0920996400001067 [pii]
AID - 10.1016/s0920-9964(00)00106-7 [doi]
PST - ppublish
SO  - Schizophr Res. 2001 Apr 15;49(1-2):65-71. doi: 10.1016/s0920-9964(00)00106-7.