PMID- 11344233
OWN - NLM
STAT- MEDLINE
DCOM- 20010531
LR  - 20061115
IS  - 0021-972X (Print)
IS  - 0021-972X (Linking)
VI  - 86
IP  - 5
DP  - 2001 May
TI  - The antral mucosa as a new site for endocrine tumors in multiple endocrine 
      neoplasia type 1 and Zollinger-Ellison syndromes.
PG  - 2236-42
AB  - Carcinoid tumors were identified in the antro-pyloric mucosa of four patients 
      with multiple endocrine neoplasia type 1 (MEN-1)/Zollinger-Ellison syndrome, 
      accounting for 8.7% of 46 patients with this condition examined by endoscopy and 
      histology. In contrast, no tumors were found in the antral biopsies from 124 
      cases of sporadic Zollinger-Ellison syndrome (P < 0.001), indicating a prominent 
      role for the MEN-1 gene defects in tumor development. Immunohistochemically the 
      tumors did not express the hormones produced by antral endocrine cells (gastrin, 
      somatostatin, serotonin). In contrast, two of them were diffusely immunoreactive 
      for the isoform 2 of the vesicular monoamine transporter (VMAT-2), a marker 
      specific for the gastric nonantral enterochromaffin-like (ECL) cells. In one of 
      these patients a second antral VMAT-2-positive carcinoid was seen 21 months after 
      the first diagnosis. The other two antral carcinoids were unreactive for VMAT-2. 
      Multiple ECL cell tumors were found in the gastric body-fundus mucosa of the two 
      patients with VMAT-2-positive, but not in those with VMAT-2-negative, antral 
      carcinoids. In one case, the former tumors were diagnosed 22 months after the 
      detection of the antral tumor. We conclude that the antral mucosa is an 
      additional tissue that may harbor endocrine tumors in MEN-1 syndrome. These 
      tumors did not express the phenotype of normal antral endocrine cells and, in at 
      least two cases, were identified as ectopic ECL cell carcinoids.
FAU - Bordi, C
AU  - Bordi C
AD  - Department of Pathology and Laboratory Medicine, Section of Pathological Anatomy, 
      University of Parma, Italy. cesare.bordi@unipr.it
FAU - Corleto, V D
AU  - Corleto VD
FAU - Azzoni, C
AU  - Azzoni C
FAU - Pizzi, S
AU  - Pizzi S
FAU - Ferraro, G
AU  - Ferraro G
FAU - Gibril, F
AU  - Gibril F
FAU - Delle Fave, G
AU  - Delle Fave G
FAU - Jensen, R T
AU  - Jensen RT
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Endocrinol Metab
JT  - The Journal of clinical endocrinology and metabolism
JID - 0375362
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Membrane Transport Proteins)
RN  - 0 (Neuropeptides)
RN  - 0 (Vesicular Biogenic Amine Transport Proteins)
RN  - 0 (Vesicular Monoamine Transport Proteins)
SB  - IM
MH  - Adult
MH  - Carcinoid Tumor/*pathology
MH  - Gastric Mucosa/pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Membrane Glycoproteins/analysis
MH  - *Membrane Transport Proteins
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*pathology
MH  - *Neuropeptides
MH  - Pyloric Antrum/pathology
MH  - Stomach Neoplasms/*pathology
MH  - Vesicular Biogenic Amine Transport Proteins
MH  - Vesicular Monoamine Transport Proteins
MH  - Zollinger-Ellison Syndrome/*pathology
EDAT- 2001/05/10 10:00
MHDA- 2001/06/02 10:01
CRDT- 2001/05/10 10:00
PHST- 2001/05/10 10:00 [pubmed]
PHST- 2001/06/02 10:01 [medline]
PHST- 2001/05/10 10:00 [entrez]
AID - 10.1210/jcem.86.5.7479 [doi]
PST - ppublish
SO  - J Clin Endocrinol Metab. 2001 May;86(5):2236-42. doi: 10.1210/jcem.86.5.7479.