PMID- 11345008
OWN - NLM
STAT- MEDLINE
DCOM- 20010920
LR  - 20071115
IS  - 1047-9651 (Print)
IS  - 1047-9651 (Linking)
VI  - 12
IP  - 2
DP  - 2001 May
TI  - The role of neurotrophic factors in disorders of peripheral nerves and motor 
      neurons.
PG  - 293-306, viii
AB  - Recent, exciting research in neurotrophic factors has significantly enhanced our 
      understanding of their actions. Neurotrophic factors have been shown to have 
      robust effects on neuronal survival and differentiation in vitro and in vivo and 
      have been tested in animal models of human neurologic disorders. These studies 
      have encouraged initiation of clinical trials of several neurotrophic factors for 
      diseases of peripheral nerves and motor neurons. In this article, the author 
      reviews the data for the actions of neurotrophic factors on peripheral nerves and 
      motor neurons, the rationale for their use in clinical trails. The results of 
      clinical trials of nerve growth factor (NGF), brain-derived neurotrophic factor 
      (BDNF), and insulin-like growth factor type 1 (IGF-1), three neurotrophic factors 
      that have been tested in phase III studies, are also reviewed.
FAU - Yuen, E C
AU  - Yuen EC
AD  - Department of Neurology, University of Washington, Seattle, Washington, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Phys Med Rehabil Clin N Am
JT  - Physical medicine and rehabilitation clinics of North America
JID - 9102787
RN  - 0 (Nerve Growth Factors)
SB  - IM
MH  - Clinical Trials as Topic
MH  - Humans
MH  - Motor Neuron Disease/diagnosis/*drug therapy/physiopathology
MH  - Nerve Growth Factors/*administration & dosage/metabolism
MH  - Neuromuscular Diseases/diagnosis/*drug therapy/physiopathology
MH  - Peripheral Nervous System Diseases/diagnosis/*drug therapy/physiopathology
MH  - Prognosis
MH  - Treatment Outcome
RF  - 56
EDAT- 2001/05/10 10:00
MHDA- 2001/09/21 10:01
CRDT- 2001/05/10 10:00
PHST- 2001/05/10 10:00 [pubmed]
PHST- 2001/09/21 10:01 [medline]
PHST- 2001/05/10 10:00 [entrez]
PST - ppublish
SO  - Phys Med Rehabil Clin N Am. 2001 May;12(2):293-306, viii.