PMID- 11345167
OWN - NLM
STAT- MEDLINE
DCOM- 20010920
LR  - 20041117
IS  - 0394-3402 (Print)
IS  - 0394-3402 (Linking)
VI  - 14
IP  - 1
DP  - 2001 Feb
TI  - Carotid intima-media thickness in patients with Type 2 diabetes and 
      hypercholesterolemia.
PG  - 58-61
AB  - Both patients with Type 2 diabetes mellitus (T2DM) and with hypercholesterolemia 
      have a more extensive and accelerated atherosclerosis with higher common carotid 
      artery intima-media thickness (CIMT) values than the general population. The aim 
      of this study was to compare the CIMT in polygenic hypercholesterolemia (HP; 
      n=41: 30 females and 11 males, aged 52+/-15 yr) and in T2DM (n=43: 22 females and 
      21 males, aged 59+/-11 yr), with a duration of disease less than 5 yr and no 
      evidence of coronary heart disease. A control group (C) of 40 sex- and 
      age-matched healthy subjects was studied. We evaluated the CIMT on the far wall 
      of the distal segment of the common carotid arteries on sites free of plaque. The 
      mean of the CIMT measurements (Tmean; 9 on each side) and the maximal CIMT 
      measured (Tmax) were used as the representative values for each subject. Tmax 
      values were 0.96+/-0.2 mm and 0.82+/-0.2 mm in T2DM and HP, respectively, which 
      were significantly higher than C (0.74+/-0.1 mm). Corresponding values of Tmean 
      were 0.8+/-0.1 mm and 0.71+/-0.2 mm, both significantly higher than C (0.68+/-0.1 
      mm). In HP, both Tmax and Tmean values were positively correlated to age 
      (p=0.0001 and p=0.0001, respectively), body mass index (BMI; p=0.05 and p=0.05, 
      respectively), presence of hypertension (p=0.003 and p=0.0008, respectively) and 
      fibrinogen (p=0.0009 and p=0.001, respectively); Tmean was also correlated to 
      apolipoprotein B (ApoB; p=0.03). The multiple "stepwise" regression analysis 
      revealed fibrinogen and age as the only significant determinants of Tmax and 
      Tmean. In T2DM Tmax and Tmean were positively correlated to age only (p=0.04 and 
      p=0.01, respectively). In conclusion, T2DM patients have a more accelerated 
      atherosclerosis than subjects with HP. This is evident after a short duration of 
      disease, probably for a longer latency period of disease and the presence of 
      multiple risk factors.
FAU - Montecchi, F R
AU  - Montecchi FR
AD  - Dipartimento di Medicina Interna, Universita di Roma Tor Vergata, Italy.
FAU - Menzinger, G
AU  - Menzinger G
FAU - Lala, A
AU  - Lala A
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Diabetes Nutr Metab
JT  - Diabetes, nutrition & metabolism
JID - 8813443
RN  - 9001-32-5 (Fibrinogen)
SB  - IM
MH  - Age Factors
MH  - Arteriosclerosis/*etiology/pathology
MH  - Carotid Artery, Common/*pathology
MH  - Diabetes Mellitus, Type 2/*complications/physiopathology
MH  - Female
MH  - Fibrinogen/analysis
MH  - Humans
MH  - Hypercholesterolemia/*complications/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Time Factors
MH  - Tunica Intima/*pathology
EDAT- 2001/05/10 10:00
MHDA- 2001/09/21 10:01
CRDT- 2001/05/10 10:00
PHST- 2001/05/10 10:00 [pubmed]
PHST- 2001/09/21 10:01 [medline]
PHST- 2001/05/10 10:00 [entrez]
PST - ppublish
SO  - Diabetes Nutr Metab. 2001 Feb;14(1):58-61.