PMID- 11348626
OWN - NLM
STAT- MEDLINE
DCOM- 20010816
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 419
IP  - 1
DP  - 2001 May 4
TI  - Antinociceptive effects of intracerebroventricularly administered P2 purinoceptor 
      agonists in the rat.
PG  - 25-31
AB  - We examined the effects of adenosine 5'-triphosphate (ATP) and its analogues 
      administered intracerebroventricularly on nociceptive thresholds in rats. 
      Intracerebroventricular (i.c.v.) administration of ATP (10 and 100 nmol/rat), 
      alpha,beta-methylene-ATP (1-30 nmol/rat) and 2', 3'-O-(4-benzoylbenzoyl)-ATP 
      (1-30 nmol/rat) dose-dependently elevated the mechanical nociceptive threshold in 
      the paw pressure test. These antinociceptive effects were rapid and 
      short-lasting, peaking at 5 min and disappearing by 20 min after the 
      administration. However, i.c.v. administration of beta,gamma-methylene-ATP (1-30 
      nmol/rat) and UTP (10 and 100 nmol/rat) had no significant effects on the 
      mechanical nociceptive threshold. In other tests, i.c.v. administration of 
      alpha,beta-methylene-ATP (10 and 30 nmol/rat) prolonged the thermal nociceptive 
      latency in the hot plate test, but only a higher dose (30 nmol/rat) of 
      alpha,beta-methylene-ATP prolonged the latency in the tail flick test. 
      alpha,beta-Methylene-ATP produced no motor deficit in the inclined plane test. 
      These results suggest that P2X purinoceptors play an inhibitory role in 
      nociception at the supraspinal level.
FAU - Fukui, M
AU  - Fukui M
AD  - Department of Molecular Pharmacology, Faculty of Pharmaceutical Sciences, Kyoto 
      University, 606-8501, Kyoto, Japan
FAU - Nakagawa, T
AU  - Nakagawa T
FAU - Minami, M
AU  - Minami M
FAU - Satoh, M
AU  - Satoh M
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Analgesics)
RN  - 0 (GABA Agonists)
RN  - 0 (Purinergic P2 Receptor Agonists)
RN  - 0 (Receptors, Purinergic P2)
RN  - 4P5DXU1F8Q (3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate)
RN  - 8L70Q75FXE (Adenosine Triphosphate)
RN  - H789N3FKE8 (Baclofen)
RN  - NYX13NT29D (alpha,beta-methyleneadenosine 5'-triphosphate)
SB  - IM
MH  - Adenosine Triphosphate/administration & dosage/*analogs & 
      derivatives/*pharmacology
MH  - Analgesics/administration & dosage/*pharmacology
MH  - Animals
MH  - Baclofen/pharmacology
MH  - GABA Agonists/pharmacology
MH  - Injections, Intraventricular
MH  - Male
MH  - Motor Activity/drug effects
MH  - Pain Measurement
MH  - Pain Threshold/*drug effects
MH  - *Purinergic P2 Receptor Agonists
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Purinergic P2/metabolism
EDAT- 2001/05/12 10:00
MHDA- 2001/08/17 10:01
CRDT- 2001/05/12 10:00
PHST- 2001/05/12 10:00 [pubmed]
PHST- 2001/08/17 10:01 [medline]
PHST- 2001/05/12 10:00 [entrez]
AID - S0014-2999(01)00947-5 [pii]
AID - 10.1016/s0014-2999(01)00947-5 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2001 May 4;419(1):25-31. doi: 10.1016/s0014-2999(01)00947-5.