PMID- 11348832
OWN - NLM
STAT- MEDLINE
DCOM- 20010705
LR  - 20190921
IS  - 0892-0362 (Print)
IS  - 0892-0362 (Linking)
VI  - 23
IP  - 2
DP  - 2001 Mar-Apr
TI  - Gestational retinoic acid exposure in the rat: effects of sex, strain and 
      exposure period.
PG  - 147-56
AB  - Effects of gestational exposure to all-trans retinoic acid (RA) were assessed in 
      the Long-Evans (hooded) and Sprague-Dawley (albino) rat strains. Two exposure 
      periods were evaluated against vehicle controls. Both involved three consecutive 
      daily per os doses of either 2.5 mg/kg RA on gestational days (GD) 11 through 13 
      or 10 mg/kg RA on GD 14 through 16. All assessments were conducted on at least 
      one male and one female per litter. Substantial main effects of sex, strain and 
      treatment were obtained, but with few significant interactions. Main effects of 
      strain were found on surface righting, neonatal mortality, litter weight and 
      postnatal day (PND) 35 regional brain weight. Among strain effects, the most 
      interesting was the finding that weights of whole brain, frontal cortex, 
      brainstem and cerebellar vermis were lower in hooded than in albino rats. These 
      strain effects seldom interacted with treatment. Among the treatment effects was 
      the finding that GD 11-13 but not GD 14-16 RA exposure impaired the righting 
      reflex in both strains. Moreover, GD 11-13 exposure reduced weight of the 
      cerebellar vermis more than did GD 14-16 RA exposure, while GD 14-16 RA exposure 
      had greater impact on the weight of the cerebellar hemispheres than did GD 11-13 
      exposure. Covariate analysis suggested that these effects were independent of 
      reductions in body weight. It is concluded that there are few strain or sex 
      differences in the effects of gestational RA exposure, at least for the rat 
      strains evaluated in this study.
FAU - Holson, R R
AU  - Holson RR
AD  - Department of Psychology, New Mexico Tech, Socorro, NM 87801, USA. 
      rholson@nmt.edu
FAU - Cogan, J E
AU  - Cogan JE
FAU - Adams, J
AU  - Adams J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neurotoxicol Teratol
JT  - Neurotoxicology and teratology
JID - 8709538
RN  - 5688UTC01R (Tretinoin)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Body Weight/drug effects
MH  - Brain/drug effects/growth & development
MH  - Female
MH  - Organ Size/drug effects
MH  - Postural Balance/drug effects
MH  - Pregnancy
MH  - Pregnancy Outcome
MH  - Rats
MH  - Rats, Long-Evans
MH  - Rats, Sprague-Dawley
MH  - Sex Characteristics
MH  - Species Specificity
MH  - Time Factors
MH  - Tretinoin/*toxicity
EDAT- 2001/05/12 10:00
MHDA- 2001/07/06 10:01
CRDT- 2001/05/12 10:00
PHST- 2001/05/12 10:00 [pubmed]
PHST- 2001/07/06 10:01 [medline]
PHST- 2001/05/12 10:00 [entrez]
AID - S0892-0362(01)00133-7 [pii]
AID - 10.1016/s0892-0362(01)00133-7 [doi]
PST - ppublish
SO  - Neurotoxicol Teratol. 2001 Mar-Apr;23(2):147-56. doi: 
      10.1016/s0892-0362(01)00133-7.