PMID- 11350518
OWN - NLM
STAT- MEDLINE
DCOM- 20011025
LR  - 20190901
IS  - 0303-6979 (Print)
IS  - 0303-6979 (Linking)
VI  - 28
IP  - 6
DP  - 2001 Jun
TI  - Experimental peri-implant mucositis in man.
PG  - 517-23
AB  - OBJECTIVES: The purpose of this study was to examine reactions of gingiva and 
      peri-implant mucosa (PiM) to de novo plaque accumulation in humans. MATERIAL AND 
      METHODS: Prior to the start of the study, which included 12 partially edentulous 
      subjects, a 3-week plaque control program was performed. Ethical approval was 
      granted by the local ethics committee. On day 0, 2 soft tissue biopsies were 
      harvested, 1 from a tooth and 1 from an implant site in every subject. After 3 
      weeks of undisturbed plaque accumulation (day 21), 2 additional biopsies were 
      obtained from the gingiva and PiM in each subject. The tissue samples, each 4x4 
      mm in size, were snap frozen and prepared for immunohistochemical analysis. 
      RESULTS: The size of the infiltrate (ICT) in the day 0 biopsies, was about 0.03 
      mm2 in both the gingiva and PiM. At the end of the plaque accumulation period, 
      the size of the lesion had significantly increased in both groups and occupied an 
      area of 0.26 mm2 in the gingiva and 0.14 mm2 in PiM. In the biopsies presenting 
      day 0, the proportions of the various cell populations examined were similar in 
      the gingiva and in PiM. The tissue fractions of almost all types of cells 
      increased during the 3 weeks, but the mean change for each cell type was greater 
      in the gingiva than in PiM. The CD3/CD19 ratio decreased in the gingiva between 
      day 0 and 21, but increased in PiM. CONCLUSION: The results of the present study 
      indicated that plaque accumulation induced an inflammatory response characterized 
      by increased proportions of T- and B-cells in the ICT of both the gingiva and the 
      PiM. Although not statistically significant, the host response in the gingiva 
      tended to be more pronounced than in the peri-implant mucosa.
FAU - Zitzmann, N U
AU  - Zitzmann NU
AD  - Clinic of Fixed and Removable Prosthodontics and TMJ Disorders, University of 
      Basel, Switzerland.
FAU - Berglundh, T
AU  - Berglundh T
FAU - Marinello, C P
AU  - Marinello CP
FAU - Lindhe, J
AU  - Lindhe J
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Clin Periodontol
JT  - Journal of clinical periodontology
JID - 0425123
RN  - 0 (Dental Implants)
SB  - IM
MH  - Aged
MH  - B-Lymphocytes/pathology
MH  - Biopsy
MH  - CD4-Positive T-Lymphocytes/pathology
MH  - CD8-Positive T-Lymphocytes/pathology
MH  - Connective Tissue/pathology
MH  - *Dental Implants
MH  - Dental Plaque/complications
MH  - Epithelial Attachment/pathology
MH  - Female
MH  - Gingiva/immunology/pathology
MH  - Gingivitis/etiology/immunology/pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Jaw, Edentulous, Partially/rehabilitation/surgery
MH  - Leukocyte Count
MH  - Lymphocyte Count
MH  - Male
MH  - Middle Aged
MH  - Neutrophils/pathology
MH  - Periodontitis/etiology/immunology/*pathology
MH  - Periodontium/immunology/pathology
MH  - Statistics as Topic
MH  - T-Lymphocytes/pathology
EDAT- 2001/05/15 10:00
MHDA- 2001/10/26 10:01
CRDT- 2001/05/15 10:00
PHST- 2001/05/15 10:00 [pubmed]
PHST- 2001/10/26 10:01 [medline]
PHST- 2001/05/15 10:00 [entrez]
AID - cpe280603 [pii]
AID - 10.1034/j.1600-051x.2001.028006517.x [doi]
PST - ppublish
SO  - J Clin Periodontol. 2001 Jun;28(6):517-23. doi: 
      10.1034/j.1600-051x.2001.028006517.x.