PMID- 11352267
OWN - NLM
STAT- MEDLINE
DCOM- 20011025
LR  - 20190921
IS  - 0074-7696 (Print)
IS  - 0074-7696 (Linking)
VI  - 207
DP  - 2001
TI  - Molecular and biochemical regulation of early mammalian development.
PG  - 195-235
AB  - Fertilization initiates a rapid series of changes that restructures the egg into 
      the zygote and initiates the program of early development. These changes in the 
      cell occur while the genetic complement of the egg and sperm are in a highly 
      condensed state and unable to participate in transcription. The egg cytoplasm, 
      formed by the maternal genome, contains the necessary components that mediate the 
      early restructuring of egg into zygote. These changes are mediated by a series of 
      cytoplasmic signal transduction events initiated by the rise in [Ca2+]i caused 
      when the sperm penetrates the egg. The structural changes that the egg undergoes 
      are rapid and result in the extensive remodeling of this specialized cell. 
      Protein kinase C (PKC) and calcium/calmodulin-dependent protein kinase II (CaM 
      KII) are two pivotal signaling agents that mediate several of these rapid 
      modifications in cell structure. Studies indicate the meiotic spindle serves as 
      an architectural element in the egg that acts to colocalize elements from several 
      of the key signaling pathways and may provide a means for these pathways to 
      interact. In mammals, transcription begins earlier than in zygotes from other 
      classes of organisms, starting several hours after fertilization in the male and 
      female pronuclei and continuing in the embryonic nuclei. Studies indicate that 
      nuclei undergo an initial state that is permissive for transcription, and then in 
      Gap 2 of the two-cell embryo, enter a transcriptionally repressive state. These 
      changes have been linked to the times during the cell cycle when the DNA is 
      replicated, and also have been proposed as a requirement for proper initiation of 
      the program of early development.
FAU - Capco, D G
AU  - Capco DG
AD  - Department of Biology, Molecular and Cellular Biology Program, Arizona State 
      University, Tempe 85287, USA.
LA  - eng
GR  - HD 32621/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Int Rev Cytol
JT  - International review of cytology
JID - 2985180R
RN  - EC 2.7.11.13 (Protein Kinase C)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinases)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Calcium/metabolism
MH  - Calcium-Calmodulin-Dependent Protein Kinases/metabolism
MH  - Cytoskeleton/metabolism
MH  - Embryo, Mammalian/*physiology
MH  - *Embryo, Nonmammalian
MH  - Embryonic and Fetal Development
MH  - Female
MH  - Fertilization/*physiology
MH  - *Gene Expression Regulation, Developmental
MH  - Male
MH  - Mitogen-Activated Protein Kinases/metabolism
MH  - Ovum/growth & development/*physiology
MH  - Protein Kinase C/metabolism
MH  - Signal Transduction/*physiology
MH  - Sperm-Ovum Interactions
MH  - Spermatozoa/physiology
RF  - 191
EDAT- 2001/05/16 10:00
MHDA- 2001/10/26 10:01
CRDT- 2001/05/16 10:00
PHST- 2001/05/16 10:00 [pubmed]
PHST- 2001/10/26 10:01 [medline]
PHST- 2001/05/16 10:00 [entrez]
AID - 10.1016/s0074-7696(01)07006-1 [doi]
PST - ppublish
SO  - Int Rev Cytol. 2001;207:195-235. doi: 10.1016/s0074-7696(01)07006-1.