PMID- 11352546
OWN - NLM
STAT- MEDLINE
DCOM- 20010823
LR  - 20181130
IS  - 1043-6618 (Print)
IS  - 1043-6618 (Linking)
VI  - 43
IP  - 4
DP  - 2001 Apr
TI  - Inhibition of immunologic and nonimmunologic stimulation-mediated anaphylactic 
      reactions by water extract of white eggplant (Solanum melongena).
PG  - 405-9
AB  - We investigated the effect of water extract of Solanum melongena(SMWE) on 
      immunologic and nonimmunologic stimulation-mediated anaphylactic reactions. 
      Nonimmunologic anaphylactic reaction was induced by compound 48/80 injection. 
      Oral administration of SMWE (1 g kg(-1)) completely inhibited compound 
      48/80-induced anaphylactic reaction. Immunologic anaphylactic reaction was 
      generated by sensitizing the skin with anti-dinitrophenyl (DNP) IgE followed 48 h 
      later with an injection of antigen. Oral administration of SMWE (0.01--1 g 
      kg(-1)) significantly inhibited passive cutaneous anaphylactic reaction activated 
      by anti-DNP IgE to between 83.10 +/- 1.67% and 70.17 +/- 2.17%. SMWE (0.01--1 mg 
      ml(-1)) also inhibited histamine release activated by compound 48/80 to between 
      93 +/- 2.65 and 70 +/- 1.50%. Moreover, SMWE (0.01--1 mg ml(-1)) had a 
      significant inhibitory effect on IgE-induced tumor necrosis factor (TNF)-alpha 
      secretion from rat peritoneal mast cells. These results indicate that SMWE 
      inhibits immunologic and nonimmunologic stimulation-mediated anaphylactic 
      reactions and TNF-alpha secretion from mast cells.
CI  - Copyright 2001 Academic Press.
FAU - Lee, Y M
AU  - Lee YM
AD  - Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, 
      Chonbuk, 570-749, Republic of Korea.
FAU - Jeong, H J
AU  - Jeong HJ
FAU - Na, H J
AU  - Na HJ
FAU - Ku, J Y
AU  - Ku JY
FAU - Kim, D K
AU  - Kim DK
FAU - Moon, G
AU  - Moon G
FAU - Chae, H J
AU  - Chae HJ
FAU - Kim, H R
AU  - Kim HR
FAU - Kim, H M
AU  - Kim HM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Pharmacol Res
JT  - Pharmacological research
JID - 8907422
RN  - 0 (Biological Factors)
RN  - 0 (Dinitrophenols)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - 820484N8I3 (Histamine)
SB  - IM
MH  - Administration, Oral
MH  - Anaphylaxis/chemically induced/*drug therapy/*immunology
MH  - Animals
MH  - Biological Factors/administration & dosage/*pharmacology/*therapeutic use
MH  - Dinitrophenols/immunology
MH  - Disease Models, Animal
MH  - Histamine/metabolism
MH  - Immunoglobulin E/immunology
MH  - Magnoliopsida/*chemistry
MH  - Mast Cells/*drug effects/*immunology/metabolism
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Rats
MH  - Tumor Necrosis Factor-alpha/metabolism
MH  - p-Methoxy-N-methylphenethylamine/antagonists & inhibitors/pharmacology
EDAT- 2001/05/16 10:00
MHDA- 2001/08/24 10:01
CRDT- 2001/05/16 10:00
PHST- 2001/05/16 10:00 [pubmed]
PHST- 2001/08/24 10:01 [medline]
PHST- 2001/05/16 10:00 [entrez]
AID - S1043661801908072 [pii]
AID - 10.1006/phrs.2001.0807 [doi]
PST - ppublish
SO  - Pharmacol Res. 2001 Apr;43(4):405-9. doi: 10.1006/phrs.2001.0807.