PMID- 11353025
OWN - NLM
STAT- MEDLINE
DCOM- 20010830
LR  - 20171213
IS  - 0022-3077 (Print)
IS  - 0022-3077 (Linking)
VI  - 85
IP  - 5
DP  - 2001 May
TI  - Short-term plasticity at inhibitory synapses in rat striatum and its effects on 
      striatal output.
PG  - 2088-99
AB  - Two forms of short-term plasticity at inhibitory synapses were investigated in 
      adult rat striatal brain slices using intracellular recordings. Intrastriatal 
      stimulation in the presence of the ionotropic glutamate receptor antagonists 
      6-cyano-7-nitroquinoxaline-2,3-dione (20 microM) and 
      D,L-2-amino-5-phosphonovaleric acid (50 microM) produced an inhibitory 
      postsynaptic potential (IPSP) that reversed polarity at -76 +/- 1 (SE) mV and was 
      sensitive to bicuculline (30 microM). The IPSP rectified at hyperpolarized 
      membrane potentials due in part to activation of K(+) channels. The IPSP 
      exhibited two forms of short-term plasticity, paired-pulse depression (PPD) and 
      synaptic augmentation. PPD lasted for several seconds and was greatest at 
      interstimulus intervals (ISIs) of several hundred milliseconds, reducing the IPSP 
      to 80 +/- 2% of its control amplitude at an ISI of 200 ms. Augmentation of the 
      IPSP, elicited by a conditioning train of 15 stimuli applied at 20 Hz, was 119 
      +/- 1% of control when sampled 2 s after the conditioning train. Augmentation 
      decayed with a time constant of 10 s. We tested if PPD and augmentation modify 
      the ability of the IPSP to prevent the generation of action potentials. A train 
      of action potentials triggered by a depolarizing current injection of constant 
      amplitude could be interrupted by stimulation of an IPSP. If this IPSP was the 
      second in a pair of IPSPs, it was less effective in blocking spikes due to PPD. 
      By contrast, augmented IPSPs were more effective in blocking spikes. The same 
      results were achieved when action potentials were triggered by a depolarizing 
      current injection of varying amplitude, a manipulation that produces nearly 
      identical spike times from trial to trial and approximates the in vivo behavior 
      of these neurons. These results demonstrate that short-term plasticity of 
      inhibition can modify the output of the striatum and thus may be an important 
      component of information processing during behaviors that involve the striatum.
FAU - Fitzpatrick, J S
AU  - Fitzpatrick JS
AD  - Leonard Davis School of Gerontology and Program in Neuroscience, University of 
      Southern California, Los Angeles, California 90089-0191, USA.
FAU - Akopian, G
AU  - Akopian G
FAU - Walsh, J P
AU  - Walsh JP
LA  - eng
GR  - AG-00093/AG/NIA NIH HHS/United States
GR  - AG-09793/AG/NIA NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurophysiol
JT  - Journal of neurophysiology
JID - 0375404
RN  - 0 (Benzazepines)
RN  - 0 (Cations, Divalent)
RN  - 0 (Dopamine Antagonists)
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (GABA Antagonists)
RN  - 0 (Muscarinic Antagonists)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Organophosphorus Compounds)
RN  - 0 (Potassium Channels)
RN  - 0 (Receptors, Dopamine)
RN  - 0 (Receptors, GABA-A)
RN  - 0 (Receptors, GABA-B)
RN  - 0 (Receptors, Muscarinic)
RN  - 6OTE87SCCW (6-Cyano-7-nitroquinoxaline-2,3-dione)
RN  - 76726-92-6 (2-Amino-5-phosphonovalerate)
RN  - 7C0697DR9I (Atropine)
RN  - 7MNE9M8287 (Sulpiride)
RN  - 87TI61875H (CGP 35348)
RN  - RWP5GA015D (Potassium)
RN  - Y37615DVKC (Bicuculline)
SB  - IM
MH  - 2-Amino-5-phosphonovalerate/pharmacology
MH  - 6-Cyano-7-nitroquinoxaline-2,3-dione/pharmacology
MH  - Action Potentials/drug effects
MH  - Animals
MH  - Atropine/pharmacology
MH  - Benzazepines/pharmacology
MH  - Bicuculline/pharmacology
MH  - Cations, Divalent/pharmacology
MH  - Corpus Striatum/*physiology
MH  - Dopamine Antagonists/pharmacology
MH  - Electric Stimulation
MH  - Evoked Potentials/drug effects
MH  - Excitatory Amino Acid Antagonists/pharmacology
MH  - GABA Antagonists/pharmacology
MH  - Ion Channel Gating/drug effects
MH  - Ion Transport/drug effects
MH  - Microinjections
MH  - Muscarinic Antagonists/pharmacology
MH  - Nerve Tissue Proteins/drug effects/physiology
MH  - Neuronal Plasticity/*physiology
MH  - Neurons/drug effects/physiology
MH  - Organophosphorus Compounds/pharmacology
MH  - Patch-Clamp Techniques
MH  - Potassium/metabolism
MH  - Potassium Channels/drug effects/physiology
MH  - Rats
MH  - Rats, Inbred F344
MH  - Receptors, Dopamine/drug effects/physiology
MH  - Receptors, GABA-A/drug effects/physiology
MH  - Receptors, GABA-B/drug effects/physiology
MH  - Receptors, Muscarinic/drug effects/physiology
MH  - Sulpiride/pharmacology
MH  - Synapses/drug effects/*physiology
EDAT- 2001/05/16 10:00
MHDA- 2001/08/31 10:01
CRDT- 2001/05/16 10:00
PHST- 2001/05/16 10:00 [pubmed]
PHST- 2001/08/31 10:01 [medline]
PHST- 2001/05/16 10:00 [entrez]
AID - 10.1152/jn.2001.85.5.2088 [doi]
PST - ppublish
SO  - J Neurophysiol. 2001 May;85(5):2088-99. doi: 10.1152/jn.2001.85.5.2088.