PMID- 11354527
OWN - NLM
STAT- MEDLINE
DCOM- 20011004
LR  - 20131121
IS  - 0172-4622 (Print)
IS  - 0172-4622 (Linking)
VI  - 22
IP  - 3
DP  - 2001 Apr
TI  - Carbohydrate beverage ingestion and neutrophil degranulation responses following 
      cycling to fatigue at 75% VO2 max.
PG  - 226-31
AB  - Carbohydrate (CHO) beverage ingestion appears to influence neutrophil functional 
      responses to prolonged exercise of a fixed duration. The aim of this randomised 
      study was to examine the effect of CHO (5% w/v) beverage ingestion on 
      lipopolysaccharide (LPS)-stimulated neutrophil degranulation responses in nine 
      recreationally active males who cycled at 75% VO2 max until fatigue. On two 
      separate occasions, subjects ingested either placebo (PLA) or CHO beverages 
      before and at 15 min intervals during the exercise. Subjects exercised for 31% 
      longer on the CHO trial compared with the PLA trial (P < 0.05). At fatigue plasma 
      glucose concentration was significantly lower on the PLA trial compared with the 
      CHO trial (P < 0.05). Plasma cortisol concentrations had increased similarly on 
      both trials at this time. A marked neutrophilia was evident at fatigue and 
      throughout the 4 h recovery period, the magnitude of which was similar on both 
      trials. At fatigue LPS-stimulated elastase release per neutrophil had fallen 
      similarly on both trials compared with pre-exercise values (47% and 50% on the 
      PLA and CHO trials, respectively). In conclusion, our results suggest that CHO 
      beverage ingestion has negligible influence on the hormonal, circulating 
      neutrophil and LPS-stimulated neutrophil degranulation responses when exercise is 
      performed to fatigue.
FAU - Bishop, N C
AU  - Bishop NC
AD  - School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, 
      England.
FAU - Blannin, A K
AU  - Blannin AK
FAU - Walsh, N P
AU  - Walsh NP
FAU - Gleeson, M
AU  - Gleeson M
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Germany
TA  - Int J Sports Med
JT  - International journal of sports medicine
JID - 8008349
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Insulin)
RN  - 33X04XA5AT (Lactic Acid)
RN  - EC 3.4.21.36 (Pancreatic Elastase)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adult
MH  - *Beverages
MH  - Bicycling/physiology
MH  - Blood Glucose/analysis/immunology
MH  - Body Mass Index
MH  - Cell Degranulation/*immunology
MH  - Dietary Carbohydrates/*immunology/metabolism
MH  - Exercise/*physiology
MH  - Fatigue/*immunology
MH  - Heart Rate/immunology
MH  - Humans
MH  - Hydrocortisone/blood/immunology
MH  - Insulin/blood
MH  - Lactic Acid/blood
MH  - Leukocyte Count
MH  - Male
MH  - Neutrophils/*immunology
MH  - Pancreatic Elastase/blood/immunology
MH  - Physical Exertion/physiology
MH  - Plasma Volume/immunology
EDAT- 2001/05/17 10:00
MHDA- 2001/10/05 10:01
CRDT- 2001/05/17 10:00
PHST- 2001/05/17 10:00 [pubmed]
PHST- 2001/10/05 10:01 [medline]
PHST- 2001/05/17 10:00 [entrez]
AID - 10.1055/s-2001-16386 [doi]
PST - ppublish
SO  - Int J Sports Med. 2001 Apr;22(3):226-31. doi: 10.1055/s-2001-16386.