PMID- 11356095
OWN - NLM
STAT- MEDLINE
DCOM- 20010802
LR  - 20181130
IS  - 0034-5288 (Print)
IS  - 0034-5288 (Linking)
VI  - 70
IP  - 2
DP  - 2001 Apr
TI  - Down-regulation of BDNF mRNA, with no effect on trkB or glucocorticoid receptor m 
      RNAs, in the porcine hippocampus after acute dexamethasone treatment.
PG  - 157-62
AB  - Glucocorticoids bind to hippocampal mineralo-(MR) and gluco-(GR) corticoid 
      receptors and, at high concentrations (e.g. as seen following treatment with 
      pharmacological doses of corticosteroids or during stress), may affect 
      hippocampal neuronal function. Such actions could involve brain-derived 
      neurotrophic factor (BDNF), its receptor, trkB, and the excitatory 
      neurotransmitter, glutamate. This experiment investigated the effect of a single 
      intravenous (i.v.) injection of the synthetic glucocorticoid, dexamethasone (Dex, 
      5 mg kg(-1)) on gene expression for MR s, GR s, BDNF, trkB, and selected 
      ionotropic glutamate receptor subunits (iGluRs), in the porcine hippocampus. 
      Quantification of m RNA s in the brains of pigs (n = 4/treatment) killed 24 hours 
      after saline or Dex administration indicated a significant Dex-induced decrease 
      in BDNF m RNA in all hippocampal regions. However, gene expression for MR s, GR 
      s, trkB and iGluRs was unaffected at this time-point.
CI  - Copyright 2001 Harcourt Publishers Ltd.
FAU - Vellucci, S V
AU  - Vellucci SV
AD  - MAFF Laboratory of Welfare and Behaviour, The Babraham Institute, Cambridge, UK. 
      sandra.vellucci@bbsrc.ac.uk
FAU - Parrott, R F
AU  - Parrott RF
FAU - Mimmack, M L
AU  - Mimmack ML
LA  - eng
PT  - Journal Article
PL  - England
TA  - Res Vet Sci
JT  - Research in veterinary science
JID - 0401300
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Glucocorticoids)
RN  - 0 (NR1 NMDA receptor)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, AMPA)
RN  - 0 (Receptors, Glucocorticoid)
RN  - 0 (Receptors, Mineralocorticoid)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 0 (glutamate receptor ionotropic, AMPA 3)
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - P6W5IXV8V9 (glutamate receptor ionotropic, AMPA 2)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/biosynthesis/*genetics
MH  - Dexamethasone/*pharmacology
MH  - Down-Regulation/drug effects
MH  - Glucocorticoids/*pharmacology
MH  - Hippocampus/*drug effects/metabolism/physiology
MH  - In Situ Hybridization/veterinary
MH  - Male
MH  - Polymerase Chain Reaction/veterinary
MH  - RNA, Messenger/biosynthesis/genetics
MH  - Receptor, trkB/biosynthesis/*genetics
MH  - Receptors, AMPA/biosynthesis/genetics
MH  - Receptors, Glucocorticoid/biosynthesis/*genetics
MH  - Receptors, Mineralocorticoid/biosynthesis/genetics
MH  - Receptors, N-Methyl-D-Aspartate/biosynthesis/genetics
MH  - Swine/*physiology
EDAT- 2001/05/18 10:00
MHDA- 2001/08/03 10:01
CRDT- 2001/05/18 10:00
PHST- 2001/05/18 10:00 [pubmed]
PHST- 2001/08/03 10:01 [medline]
PHST- 2001/05/18 10:00 [entrez]
AID - S0034-5288(01)90456-4 [pii]
AID - 10.1053/rvsc.2001.0456 [doi]
PST - ppublish
SO  - Res Vet Sci. 2001 Apr;70(2):157-62. doi: 10.1053/rvsc.2001.0456.