PMID- 11356878
OWN - NLM
STAT- MEDLINE
DCOM- 20010621
LR  - 20181113
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Print)
IS  - 0270-6474 (Linking)
VI  - 21
IP  - 11
DP  - 2001 Jun 1
TI  - Target-derived neurotrophic factors regulate the death of developing forebrain 
      neurons after a change in their trophic requirements.
PG  - 3904-10
AB  - Many neurons die as the normal brain develops. How this is regulated and whether 
      the mechanism involves neurotrophic molecules from target cells are unknown. We 
      found that cultured neurons from a key forebrain structure, the dorsal thalamus, 
      develop a need for survival factors including brain-derived neurotrophic factor 
      (BDNF) from their major target, the cerebral cortex, at the age at which they 
      innervate it. Experiments in vivo have shown that rates of dorsal thalamic cell 
      death are reduced by increasing cortical levels of BDNF and are increased in 
      mutant mice lacking functional BDNF receptors or thalamocortical projections; 
      these experiments have also shown that an increase in the rates of dorsal 
      thalamic cell death can be achieved by blocking BDNF in the cortex. We suggest 
      that the onset of a requirement for cortex-derived neurotrophic factors initiates 
      a competitive mechanism regulating programmed cell death among dorsal thalamic 
      neurons.
FAU - Lotto, R B
AU  - Lotto RB
AD  - Genes and Development Group, Department of Biomedical Sciences, University 
      Medical School, Edinburgh EH8 9XD, United Kingdom.
FAU - Asavaritikrai, P
AU  - Asavaritikrai P
FAU - Vali, L
AU  - Vali L
FAU - Price, D J
AU  - Price DJ
LA  - eng
GR  - Wellcome Trust/United Kingdom
GR  - 065620/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
RN  - 0 (Antibodies)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Culture Media, Conditioned)
RN  - 0 (Eye Proteins)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (PAX6 Transcription Factor)
RN  - 0 (Paired Box Transcription Factors)
RN  - 0 (Pax6 protein, mouse)
RN  - 0 (Receptors, Nerve Growth Factor)
RN  - 0 (Repressor Proteins)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 2.7.10.1 (Receptor, trkC)
SB  - IM
MH  - Animals
MH  - Antibodies/pharmacology
MH  - Apoptosis/drug effects/genetics
MH  - Brain-Derived Neurotrophic Factor/antagonists & 
      inhibitors/metabolism/pharmacology
MH  - Cell Survival/drug effects/genetics
MH  - Cells, Cultured
MH  - Cerebral Cortex/cytology/metabolism
MH  - Culture Media, Conditioned/pharmacology
MH  - Eye Proteins
MH  - Gene Expression Regulation, Developmental
MH  - Homeodomain Proteins/genetics/metabolism
MH  - In Situ Nick-End Labeling
MH  - Mice
MH  - Mice, Knockout
MH  - Nerve Growth Factors/antagonists & inhibitors/*metabolism/pharmacology
MH  - Neural Pathways/cytology/embryology/metabolism
MH  - Neurons/cytology/drug effects/*metabolism
MH  - PAX6 Transcription Factor
MH  - Paired Box Transcription Factors
MH  - Prosencephalon/cytology/drug effects/embryology/*metabolism
MH  - Receptor, trkB/deficiency/genetics
MH  - Receptor, trkC/deficiency/genetics
MH  - Receptors, Nerve Growth Factor/deficiency/genetics/metabolism
MH  - Repressor Proteins
MH  - Thalamic Nuclei/cytology/embryology/metabolism
MH  - Thalamus/cytology/drug effects/embryology/metabolism
PMC - PMC6207345
MID - EMS80192
EDAT- 2001/05/23 10:00
MHDA- 2001/06/22 10:01
PMCR- 2001/12/01
CRDT- 2001/05/23 10:00
PHST- 2001/05/23 10:00 [pubmed]
PHST- 2001/06/22 10:01 [medline]
PHST- 2001/05/23 10:00 [entrez]
PHST- 2001/12/01 00:00 [pmc-release]
AID - 21/11/3904 [pii]
AID - 5277 [pii]
AID - 10.1523/JNEUROSCI.21-11-03904.2001 [doi]
PST - ppublish
SO  - J Neurosci. 2001 Jun 1;21(11):3904-10. doi: 10.1523/JNEUROSCI.21-11-03904.2001.