PMID- 11357166
OWN - NLM
STAT- MEDLINE
DCOM- 20010726
LR  - 20191025
IS  - 0049-0172 (Print)
IS  - 0049-0172 (Linking)
VI  - 30
IP  - 5 Suppl 2
DP  - 2001 Apr
TI  - Uncoupling of inflammatory and destructive mechanisms in arthritis.
PG  - 7-16
AB  - OBJECTIVE: To update clinicians on recent advances in the differentiation of the 
      mechanisms of inflammation and cartilage destruction in the pathogenesis of 
      rheumatoid arthritis (RA). METHODS: We present analysis of recent published 
      literature and abstracts that elucidates the independent actions of pivotal 
      proinflammatory cytokines. These experimental data provide the framework for 
      understanding the uncoupling of destructive and inflammatory mechanisms in 
      arthritis. RESULTS: Tumor necrosis factor-alpha (TNF-alpha) is an important 
      mediator in the inflammation that occurs in RA. Interleukin-1 (IL-1) has a 
      dominant effect on cartilage destruction that occurs later in the disease 
      process. TNF-independent IL-1 production occurs in many RA model situations. 
      Cytokine balance determines the erosive nature of the disease. CONCLUSION: IL-1 
      is at least as important as TNF-alpha in promoting the disease process. The 
      pathways by which the inflammatory and destructive changes occur suggest that 
      targeted anticytokine intervention will arrest the cartilage damage that occurs 
      in patients with RA.
CI  - Copyright 2001 by W.B. Saunders Company.
FAU - van den Berg, W B
AU  - van den Berg WB
AD  - Department of Rheumatology, University Medical Center, Nijmegen, The Netherlands.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Semin Arthritis Rheum
JT  - Seminars in arthritis and rheumatism
JID - 1306053
RN  - 0 (Enzymes)
RN  - 0 (Interleukin-1)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Animals
MH  - Arthritis, Rheumatoid/*etiology/*pathology/physiopathology
MH  - Cartilage, Articular/pathology/physiopathology
MH  - Enzymes/physiology
MH  - Humans
MH  - Interleukin-1/physiology
MH  - Tumor Necrosis Factor-alpha/physiology
RF  - 30
EDAT- 2001/05/18 10:00
MHDA- 2001/07/28 10:01
CRDT- 2001/05/18 10:00
PHST- 2001/05/18 10:00 [pubmed]
PHST- 2001/07/28 10:01 [medline]
PHST- 2001/05/18 10:00 [entrez]
AID - asarh0300007b [pii]
AID - 10.1053/sarh.2001.23704 [doi]
PST - ppublish
SO  - Semin Arthritis Rheum. 2001 Apr;30(5 Suppl 2):7-16. doi: 10.1053/sarh.2001.23704.