PMID- 11357950
OWN - NLM
STAT- MEDLINE
DCOM- 20010614
LR  - 20111117
IS  - 0364-5134 (Print)
IS  - 0364-5134 (Linking)
VI  - 49
IP  - 5
DP  - 2001 May
TI  - Neuropeptides and neurotrophins in neonatal blood of children with autism or 
      mental retardation.
PG  - 597-606
AB  - There has been little exploration of major biologic regulators of cerebral 
      development in autism. In archived neonatal blood of children with autistic 
      spectrum disorders (n = 69), mental retardation without autism (n = 60), or 
      cerebral palsy (CP, n = 63) and of control children (n = 54), we used recycling 
      immunoaffinity chromatography to measure the neuropeptides substance P (SP), 
      vasoactive intestinal peptide (VIP), pituitary adenylate cyclase-activating 
      polypeptide (PACAP), calcitonin gene-related peptide (CGRP), and the 
      neurotrophins nerve growth factor (NGF), brain-derived neurotrophic factor 
      (BDNF), neurotrophin 3 (NT3), and neurotrophin 4/5 (NT4/5). Neonatal 
      concentrations of VIP, CGRP, BDNF, and NT4/5 were higher (ANOVA, all p values < 
      0.0001 by Scheffe test for pairwise differences) in children in the autistic 
      spectrum and in those with mental retardation without autism than in control 
      children. In 99% of children with autism and 97% with mental retardation, levels 
      of at least one of these substances exceeded those of all control children. 
      Concentrations were similar in subgroups of the autistic spectrum (core syndrome 
      with or without mental retardation, other autistic spectrum disorders with or 
      without mental retardation) and in the presence or absence of a history of 
      regression. Among children with mental retardation, concentrations did not differ 
      by severity or known cause (n = 11, including 4 with Down syndrome). 
      Concentrations of measured substances were similar in children with CP as 
      compared with control subjects. SP, PACAP, NGF, and NT3 were not different by 
      diagnostic group. No measured analyte distinguished children with autism from 
      children with mental retardation alone. In autism and in a heterogeneous group of 
      disorders of cognitive function, overexpression of certain neuropeptides and 
      neurotrophins was observed in peripheral blood drawn in the first days of life.
FAU - Nelson, K B
AU  - Nelson KB
AD  - National Institute of Neurological Diseases and Stroke, Bethesda, MD 20892-1447, 
      USA. knelson@helix.nih.gov
FAU - Grether, J K
AU  - Grether JK
FAU - Croen, L A
AU  - Croen LA
FAU - Dambrosia, J M
AU  - Dambrosia JM
FAU - Dickens, B F
AU  - Dickens BF
FAU - Jelliffe, L L
AU  - Jelliffe LL
FAU - Hansen, R L
AU  - Hansen RL
FAU - Phillips, T M
AU  - Phillips TM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Ann Neurol
JT  - Annals of neurology
JID - 7707449
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neuropeptides)
SB  - IM
MH  - Autistic Disorder/*blood
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Intellectual Disability/*blood
MH  - Male
MH  - Nerve Growth Factors/*blood
MH  - Neuropeptides/*blood
EDAT- 2001/05/19 10:00
MHDA- 2001/06/23 10:01
CRDT- 2001/05/19 10:00
PHST- 2001/05/19 10:00 [pubmed]
PHST- 2001/06/23 10:01 [medline]
PHST- 2001/05/19 10:00 [entrez]
PST - ppublish
SO  - Ann Neurol. 2001 May;49(5):597-606.