PMID- 11358454
OWN - NLM
STAT- MEDLINE
DCOM- 20010705
LR  - 20161124
IS  - 0014-4886 (Print)
IS  - 0014-4886 (Linking)
VI  - 169
IP  - 2
DP  - 2001 Jun
TI  - Differences in neurotrophic factor gene expression profiles between neonate and 
      adult rat spinal cord after injury.
PG  - 407-15
AB  - The capacity of the central nervous system for axonal growth decreases as the age 
      of the animal at the time of injury increases. Changes in the expression of 
      neurotrophic factors within embryonic and early postnatal spinal cord suggest 
      that a lack of trophic support contributes to this restrictive growth 
      environment. We examined neurotrophic factor gene profiles by ribonuclease 
      protection assay in normal neonate and normal adult spinal cord and in neonate 
      and adult spinal cord after injury. Our results show that in the normal 
      developing spinal cord between postnatal days 3 (P3) and P10, compared to the 
      normal adult spinal cord, there are higher levels of nerve growth factor (NGF), 
      brain-derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), and 
      glial-derived neurotrophic factor (GDNF) mRNA expression and a lower level of 
      ciliary neurotrophic factor (CNTF) mRNA expression. Between P10 and P17, there is 
      a significant decrease in the expression of NGF, BDNF, NT-3, and GDNF mRNA and a 
      contrasting steady and significant increase in the level of CNTF mRNA expression. 
      These findings show that there is a critical shift in neurotrophic factor 
      expression in normal developing spinal cord between P10 and P17. In neonate 
      spinal cord after injury, there is a significantly higher level of BDNF mRNA 
      expression and a significantly lower level of CNTF mRNA expression compared to 
      those observed in the adult spinal cord after injury. These findings suggest that 
      high levels of BDNF mRNA expression and low levels of CNTF mRNA expression play 
      important roles in axonal regrowth in early postnatal spinal cord after injury.
CI  - Copyright 2001 Academic Press.
FAU - Nakamura, M
AU  - Nakamura M
AD  - Department of Neuroscience, Georgetown University Medical Center, Washington, DC 
      20007, USA.
FAU - Bregman, B S
AU  - Bregman BS
LA  - eng
GR  - NS19259/NS/NINDS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Exp Neurol
JT  - Experimental neurology
JID - 0370712
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Ciliary Neurotrophic Factor)
RN  - 0 (Gdnf protein, rat)
RN  - 0 (Glial Cell Line-Derived Neurotrophic Factor)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neurotrophin 3)
RN  - 9061-61-4 (Nerve Growth Factor)
RN  - P658DCA9XD (neurotrophin 4)
SB  - IM
MH  - Aging/*metabolism
MH  - Animals
MH  - Animals, Newborn
MH  - Brain-Derived Neurotrophic Factor/genetics
MH  - Ciliary Neurotrophic Factor/genetics
MH  - *Gene Expression Regulation, Developmental
MH  - Glial Cell Line-Derived Neurotrophic Factor
MH  - Nerve Growth Factor/genetics
MH  - Nerve Growth Factors/*genetics
MH  - Nerve Tissue Proteins/genetics
MH  - Neurotrophin 3/genetics
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reference Values
MH  - Spinal Cord/growth & development/*metabolism
MH  - Spinal Cord Injuries/*metabolism
EDAT- 2001/05/19 10:00
MHDA- 2001/07/06 10:01
CRDT- 2001/05/19 10:00
PHST- 2001/05/19 10:00 [pubmed]
PHST- 2001/07/06 10:01 [medline]
PHST- 2001/05/19 10:00 [entrez]
AID - S0014-4886(01)97670-8 [pii]
AID - 10.1006/exnr.2001.7670 [doi]
PST - ppublish
SO  - Exp Neurol. 2001 Jun;169(2):407-15. doi: 10.1006/exnr.2001.7670.