PMID- 11359594
OWN - NLM
STAT- MEDLINE
DCOM- 20010705
LR  - 20190921
IS  - 1155-5645 (Print)
IS  - 1155-5645 (Linking)
VI  - 11
IP  - 3
DP  - 2001 May
TI  - Postoperative nausea and vomiting in paediatric ambulatory surgery: sevoflurane 
      versus spinal anaesthesia with propofol sedation.
PG  - 337-42
AB  - BACKGROUND: Descriptive data report a very low rate of postoperative nausea and 
      vomiting (PONV) following spinal anaesthesia in children. In an attempt to 
      corroborate this observation, we designed a prospective randomized study to 
      compare spinal anaesthesia with intravenous propofol sedation (SA) (n=21) to 
      inhalational sevoflurane anaesthesia (IA) (n=19) with regard to PONV and 
      postoperative analgesia in children (aged 3-12 years) undergoing ambulatory 
      inguinal surgery. RESULTS: No difference was found concerning the number of 
      patients experiencing PONV in each group (SA 1/21 versus IA 5/19; P=0.085). 
      However, spinal anaesthesia was associated with a reduced number of PONV episodes 
      (1/21) compared with inhalation anaesthesia (8/19) (P=0.014) and the need for 
      supplemental postoperative analgesia with ketoralac was significantly lower in 
      the SA group (3/21) compared to the IA group (14/19) (P < 0.001). Despite these 
      benefits of spinal anaesthesia compared with inhalational anaesthesia, spinal 
      anaesthesia did not decrease the time to discharge from the ambulatory surgery 
      unit [SA 161 (SD 51) min, IA 164 (SD 41) min; P=NS] and the overall PONV 
      experience was rated as "no problem" by all patients, except one, regardless of 
      anaesthetic protocol used. CONCLUSIONS: Despite the reduced number of emetic 
      episodes and the better immediate postoperative analgesia associated with spinal 
      anaesthesia, no difference could be identified between the two different 
      anaesthetic protocols regarding time to discharge or overall patient 
      satisfaction. Thus, despite minor advantages associated with spinal anaesthesia 
      with propofol sedation, both anaesthetic regimen appear equally suitable for use 
      in the paediatric outpatient setting.
FAU - Oddby, E
AU  - Oddby E
AD  - Department of Anaesthesia and Intensive Care, Danderyd Hospital, S-182 88 
      Danderyd, Sweden. eva oddby@ane.ds.sll.se
FAU - Englund, S
AU  - Englund S
FAU - Lonnqvist, P A
AU  - Lonnqvist PA
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - France
TA  - Paediatr Anaesth
JT  - Paediatric anaesthesia
JID - 9206575
RN  - 0 (Anesthetics, Inhalation)
RN  - 0 (Anesthetics, Intravenous)
RN  - 0 (Methyl Ethers)
RN  - 38LVP0K73A (Sevoflurane)
RN  - YI7VU623SF (Propofol)
SB  - IM
MH  - *Ambulatory Surgical Procedures
MH  - Anesthesia, Inhalation/*adverse effects
MH  - Anesthesia, Spinal/*adverse effects
MH  - Anesthetics, Inhalation/*adverse effects
MH  - Anesthetics, Intravenous/*adverse effects
MH  - Child
MH  - Child, Preschool
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Male
MH  - Methyl Ethers/*adverse effects
MH  - Postoperative Nausea and Vomiting/*epidemiology
MH  - Preanesthetic Medication
MH  - Propofol/*adverse effects
MH  - Prospective Studies
MH  - Sevoflurane
EDAT- 2001/05/22 10:00
MHDA- 2001/07/06 10:01
CRDT- 2001/05/22 10:00
PHST- 2001/05/22 10:00 [pubmed]
PHST- 2001/07/06 10:01 [medline]
PHST- 2001/05/22 10:00 [entrez]
AID - pan670 [pii]
AID - 10.1046/j.1460-9592.2001.00670.x [doi]
PST - ppublish
SO  - Paediatr Anaesth. 2001 May;11(3):337-42. doi: 10.1046/j.1460-9592.2001.00670.x.