PMID- 11359956
OWN - NLM
STAT- MEDLINE
DCOM- 20010705
LR  - 20190503
IS  - 0040-6376 (Print)
IS  - 1468-3296 (Electronic)
IS  - 0040-6376 (Linking)
VI  - 56
IP  - 6
DP  - 2001 Jun
TI  - Dendritic cells in the mucosa of the human trachea are not regularly found in the 
      first year of life.
PG  - 427-31
AB  - BACKGROUND: Dendritic cells (DCs) in the mucosa of the respiratory tract might be 
      involved in the early development of pulmonary allergy or tolerance. To date, 
      little is known about when the first DCs occur in human airways. METHODS: 
      Specimens of the distal trachea from patients who had died from sudden death in 
      the first year of life (n=29) and in older age groups (n=59) as well as from 
      those who had died from respiratory tract infections in the first year of life 
      (n=8) were examined by immunohistochemistry. Transmission electron microscopy was 
      performed in additional samples from two adults. RESULTS: In the sudden death 
      subgroup DCs were absent in 76% of those who died in the first year of life but 
      were present in 53 of the 59 older cases. All infants who had died of respiratory 
      infectious diseases had DCs in the tracheal mucosa. CONCLUSIONS: Mature DCs are 
      not constitutively present in the human tracheobronchial mucosa in the first year 
      of life, but their occurrence seems to be triggered by infectious stimuli. These 
      data support the hypothesis that DCs play a crucial role in immunoregulation in 
      early childhood.
FAU - Tschernig, T
AU  - Tschernig T
AD  - Department of Anatomy, Medical School of Hannover, 30623 Hannover, Germany. 
      Tschernig.Thomas@MH-Hannover.de
FAU - Debertin, A S
AU  - Debertin AS
FAU - Paulsen, F
AU  - Paulsen F
FAU - Kleemann, W J
AU  - Kleemann WJ
FAU - Pabst, R
AU  - Pabst R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Thorax
JT  - Thorax
JID - 0417353
SB  - IM
CIN - Thorax. 2001 Jun;56(6):419-20. PMID: 11359953
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Autopsy
MH  - Child
MH  - Child, Preschool
MH  - Death, Sudden/pathology
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Immunity, Cellular
MH  - Immunohistochemistry/methods
MH  - Infant
MH  - Infant, Newborn
MH  - Middle Aged
MH  - Respiratory Hypersensitivity/immunology/pathology
MH  - Respiratory Mucosa/*immunology
MH  - Respiratory Tract Diseases/immunology/pathology
MH  - Retrospective Studies
MH  - Sudden Infant Death/immunology/pathology
MH  - Trachea/*immunology
MH  - Virus Diseases/immunology
PMC - PMC1746069
EDAT- 2001/05/22 10:00
MHDA- 2001/07/06 10:01
PMCR- 2004/06/01
CRDT- 2001/05/22 10:00
PHST- 2001/05/22 10:00 [pubmed]
PHST- 2001/07/06 10:01 [medline]
PHST- 2001/05/22 10:00 [entrez]
PHST- 2004/06/01 00:00 [pmc-release]
AID - 10.1136/thorax.56.6.427 [doi]
PST - ppublish
SO  - Thorax. 2001 Jun;56(6):427-31. doi: 10.1136/thorax.56.6.427.