PMID- 11367975
OWN - NLM
STAT- MEDLINE
DCOM- 20010802
LR  - 20091111
IS  - 0044-2771 (Print)
IS  - 0044-2771 (Linking)
VI  - 39
IP  - 4
DP  - 2001 Apr
TI  - [Stimulation of immunoglobulin E formation in chronic pancreatitis by alcohol 
      drinking and exocrine pancreatic insufficiency].
PG  - 269-76
AB  - Many patients with chronic pancreatitis (CP) complain of several types of food 
      intolerance despite elimination of fat and alcohol. Since there are no data on 
      serum immunoglobulin E (IgE) concentrations in CP, IgE concentrations in serum 
      were detected in 97 persons with CP and 50 controls. IgE was analyzed by the use 
      of a highly sensitive fluoro-enzyme-immunoassay. In CP, a significantly raised 
      IgE level (mean +/- SEM; 286.1 +/- 49 KU/L; p < 0.0001) was detected compared 
      with controls (65.2 +/- 13 KU/L). CP-patients without alcohol consumption and 
      normal exocrine pancreatic function were found to have only slightly elevated 
      serum IgE values (120.2 +/- 54 KU/L), whereas patients with exocrine 
      insufficiency treated with enzyme supplementation showed an IgE level of 153.7 
      +/- 51 and exocrine insufficient patients without treatment of 261.0 +/- 173 KU/L 
      (p = 0.01). IgE levels were far more elevated in the corresponding groups with 
      continued alcohol consumption (> 25 g/day). Alcohol consuming patients with CP 
      and normal pancreatic function had a mean serum IgE of 295.0 +/- 114 KU/L, while 
      patients with alcohol consumption and sufficiently treated exocrine pancreatic 
      insufficiency showed a serum IgE of 393.7 +/- 147 KU/L (p = 0.03). Non-enzyme 
      supplemented patients with CP and exocrine pancreatic insufficiency were 
      characterized by approximately 10-fold increased serum IgE (1080.0 +/- 313 KU/L; 
      p = 0.001). Non-allergic, alcohol consuming patients with CP have significantly 
      increased serum IgE values. Since patients without alcohol consumption and normal 
      pancreatic function or sufficiently treated exocrine insufficiency showed clearly 
      lower IgE values than non-compliant patients with manifest exocrine pancreatic 
      insufficiency, these results are compatible with the assumption that a reduced 
      rate of antigen digestion in exocrine pancreatic insufficiency may lead to an 
      increased intestinal antigen load, stimulating an abnormal humoral immune 
      response with IgE production. Alcohol may further contribute to this by damaging 
      the mucosal barrier.
FAU - Raithel, M
AU  - Raithel M
AD  - Funktionelle Gewebediagnostik Med. Klinik I, Universitat Erlangen-Nurnberg. 
      Martin.Raithel@med1.imed.uni-erlangen.de
FAU - Dormann, H
AU  - Dormann H
FAU - Farnbacher, M
AU  - Farnbacher M
FAU - Weidenhiller, M
AU  - Weidenhiller M
FAU - Hahn, E G
AU  - Hahn EG
FAU - Schneider, H T
AU  - Schneider HT
LA  - ger
PT  - English Abstract
PT  - Journal Article
TT  - Stimulation der Immunoglobulin-E-Bildung bei chronischer Pankreatitis durch 
      Alkoholaufnahme und exokrine Pankreasinsuffizienz.
PL  - Germany
TA  - Z Gastroenterol
JT  - Zeitschrift fur Gastroenterologie
JID - 0033370
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Alcohol Drinking/*adverse effects/immunology
MH  - Chronic Disease
MH  - Exocrine Pancreatic Insufficiency/*immunology
MH  - Female
MH  - Food Hypersensitivity/*immunology
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Middle Aged
MH  - Pancreatitis/*immunology
MH  - Risk Factors
MH  - Treatment Refusal
EDAT- 2001/05/23 10:00
MHDA- 2001/08/03 10:01
CRDT- 2001/05/23 10:00
PHST- 2001/05/23 10:00 [pubmed]
PHST- 2001/08/03 10:01 [medline]
PHST- 2001/05/23 10:00 [entrez]
AID - 10.1055/s-2001-12870 [doi]
PST - ppublish
SO  - Z Gastroenterol. 2001 Apr;39(4):269-76. doi: 10.1055/s-2001-12870.