PMID- 11369054
OWN - NLM
STAT- MEDLINE
DCOM- 20010906
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 125
IP  - 2
DP  - 2001 Mar
TI  - Loss of 1p in recurrent meningiomas. a comparative study in successive 
      recurrences by cytogenetics and fluorescence in situ hybridization.
PG  - 119-24
AB  - Deletion of 1p is associated with histological progression to meningiomas. 
      Detection of this alteration may be a predicting factor for recurrences in this 
      tumor. We present 8 meningiomas from four patients: the original tumor and the 
      first recurrence in one patient, and the first and second recurrences in the 
      other three were studied. We compared results of monosomy 22 and deletion of 
      chromosome 1p with cytogenetic methods and fluorescence in situ hybridization 
      (FISH) analysis obtained from slides of direct preparations, of cultured cells 
      and slides of touch preparations. The cytogenetic study showed normal chromosome 
      22 and deletion on 1p32 in both samples of one patient; only monosomy 22 in both 
      recurrences in another patient, and normal karyotypes with different non-clonal 
      anomalies in the other tumors. However, with FISH analysis, monosomy 22 in both 
      recurrences of three patients was demonstrated, as well as the loss of 1p in all 
      tumors. These results were more evident in the analysis of direct and touch 
      preparations than in those of cultured cells.
FAU - Lopez-Gines, C
AU  - Lopez-Gines C
AD  - Department of Pathology, Medical School, University of Valencia, Av. Blasco 
      Ibanez, 17, 46010, Valencia, Spain. concha.lopez@uv.es
FAU - Cerda-Nicolas, M
AU  - Cerda-Nicolas M
FAU - Gil-Benso, R
AU  - Gil-Benso R
FAU - Barcia-Salorio, J L
AU  - Barcia-Salorio JL
FAU - Llombart-Bosch, A
AU  - Llombart-Bosch A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chromosome Breakage
MH  - *Chromosome Deletion
MH  - Chromosomes, Human, Pair 1/*ultrastructure
MH  - Chromosomes, Human, Pair 22
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Male
MH  - Meningeal Neoplasms/*genetics/pathology/surgery
MH  - Meningioma/*genetics/pathology/surgery
MH  - Middle Aged
MH  - Monosomy
MH  - Neoplasm Recurrence, Local/*genetics/pathology
MH  - Tumor Cells, Cultured/ultrastructure
EDAT- 2001/05/23 10:00
MHDA- 2001/09/08 10:01
CRDT- 2001/05/23 10:00
PHST- 2001/05/23 10:00 [pubmed]
PHST- 2001/09/08 10:01 [medline]
PHST- 2001/05/23 10:00 [entrez]
AID - S0165-4608(00)00365-4 [pii]
AID - 10.1016/s0165-4608(00)00365-4 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2001 Mar;125(2):119-24. doi: 
      10.1016/s0165-4608(00)00365-4.