PMID- 11369063
OWN - NLM
STAT- MEDLINE
DCOM- 20010906
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 125
IP  - 2
DP  - 2001 Mar
TI  - Insertion (22;9)(q11;q34q21) in a patient with chronic myeloid leukemia 
      characterized by fluorescence in situ hybridization.
PG  - 167-70
AB  - An unusual cytogenetic rearrangement, described as ins(22;9)(q11;q34q21), was 
      detected in a 49-year-old male patient diagnosed with chronic myeloid leukemia 
      (CML). Reverse transcriptase polymerase chain reaction (RT-PCR) revealed a b3a2 
      fusion transcript. In order to confirm the cytogenetic findings and fully 
      characterize the inverted insertion, we performed fluorescence in situ 
      hybridization (FISH) assays using locus-specific and whole chromosome painting 
      probes. Our FISH analysis showed the presence of the BCR/ABL fusion gene, 
      verified the insertion and determined that the breakpoint on chromosome 22 where 
      the insertion took place was located proximal to the BCR gene and distal to the 
      TUPLE1 gene on 22q11.
FAU - Martin-Subero, J I
AU  - Martin-Subero JI
AD  - Department of Genetics, University of Navarra, Irunlarrea s/n, 31008, Pamplona, 
      Spain.
FAU - Lahortiga, I
AU  - Lahortiga I
FAU - Gomez, E
AU  - Gomez E
FAU - Ferreira, C
AU  - Ferreira C
FAU - Larrayoz, M J
AU  - Larrayoz MJ
FAU - Odero, M D
AU  - Odero MD
FAU - Garcia-Delgado, M
AU  - Garcia-Delgado M
FAU - Novo, F J
AU  - Novo FJ
FAU - Giraldo, P
AU  - Giraldo P
FAU - Calasanz, M J
AU  - Calasanz MJ
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Biomarkers, Tumor)
RN  - EC 2.7.10.2 (Fusion Proteins, bcr-abl)
SB  - IM
MH  - Biomarkers, Tumor/analysis/*genetics
MH  - Bone Marrow/pathology
MH  - Chromosome Banding
MH  - Chromosome Breakage
MH  - *Chromosome Inversion
MH  - Chromosome Painting
MH  - Chromosomes, Human, Pair 22/genetics/*ultrastructure
MH  - Chromosomes, Human, Pair 9/genetics/*ultrastructure
MH  - Clone Cells/pathology
MH  - Fusion Proteins, bcr-abl/analysis/*genetics
MH  - Humans
MH  - Karyotyping
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*genetics/metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Models, Genetic
MH  - Mutagenesis, Insertional
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - *Translocation, Genetic
EDAT- 2001/05/23 10:00
MHDA- 2001/09/08 10:01
CRDT- 2001/05/23 10:00
PHST- 2001/05/23 10:00 [pubmed]
PHST- 2001/09/08 10:01 [medline]
PHST- 2001/05/23 10:00 [entrez]
AID - S0165-4608(00)00370-8 [pii]
AID - 10.1016/s0165-4608(00)00370-8 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2001 Mar;125(2):167-70. doi: 
      10.1016/s0165-4608(00)00370-8.