PMID- 11369514
OWN - NLM
STAT- MEDLINE
DCOM- 20010809
LR  - 20221207
IS  - 0898-6568 (Print)
IS  - 0898-6568 (Linking)
VI  - 13
IP  - 5
DP  - 2001 May
TI  - Tumor necrosis factor-alpha is induced through phorbol ester--and glycated human 
      albumin-dependent pathway in THP-1 cells.
PG  - 331-4
AB  - Tumor necrosis factor-alpha (TNF-alpha) is involved in insulin resistance. Since 
      the fact that peroxisome proliferator-activated receptor gamma (PPARgamma) 
      ligands inhibit the induction of TNF-alpha by phorbol ester, but not by 
      lipopolysaccharide (LPS), suggests two pathways to induce TNF-alpha, we 
      investigated the mechanisms of glycated human albumin (GHA)- or phorbol 
      ester-induced TNF-alpha in THP-1 cells. GHA induced TNF-alpha release in 
      differentiated THP-1 cells, while phorbol ester induced TNF-alpha release in 
      undifferentiated cells but did not induce TNF-alpha in differentiated cells. 
      Forskolin (adenylate cyclase activator) affected more the GHA-induced TNF-alpha 
      release than the phorbol 12-myristate 13-acetate (PMA)-induced one in 
      undifferentiated cells. Staurosporine [protein kinase-C (PK-C) inhibitor] and 
      PD98059 [mitogen-activated protein kinase inhibitor (MAPK)] only partially 
      inhibited GHA-induced TNF-alpha. Catalase completely inhibited GHA-induced 
      TNF-alpha release; however, superoxide dismutase (SOD) had no effect. These 
      results suggest at least two pathways to induce TNF-alpha (phorbol ester- and 
      GHA-dependent ways) and that GHA-induced TNF-alpha release is through 
      predominantly catalase-dependent way in differentiated THP-1 cells.
FAU - Naitoh, T
AU  - Naitoh T
AD  - Nissan Chemical Industries, Ltd., Shiraoka Research Station of Biological 
      Science, 1470 Shiraoka, Minamisaitama, 349-0294, Saitama, Japan. 
      naitouta@nissanchem.co.jp
FAU - Kitahara, M
AU  - Kitahara M
FAU - Tsuruzoe, N
AU  - Tsuruzoe N
LA  - eng
PT  - Journal Article
PL  - England
TA  - Cell Signal
JT  - Cellular signalling
JID - 8904683
RN  - 0 (Carcinogens)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Flavonoids)
RN  - 0 (Glycation End Products, Advanced)
RN  - 0 (Serum Albumin)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 1F7A44V6OU (Colforsin)
RN  - E0399OZS9N (Cyclic AMP)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - EC 2.7.11.13 (Protein Kinase C)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - H88EPA0A3N (Staurosporine)
RN  - NI40JAQ945 (Tetradecanoylphorbol Acetate)
RN  - SJE1IO5E3I (2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one)
RN  - 0 (Glycated Serum Albumin)
SB  - IM
MH  - Carcinogens/*pharmacology
MH  - Catalase/pharmacology
MH  - Cell Differentiation/physiology
MH  - Cell Line
MH  - Colforsin/pharmacology
MH  - Cyclic AMP/metabolism
MH  - Dose-Response Relationship, Drug
MH  - Enzyme Inhibitors/pharmacology
MH  - Flavonoids/pharmacology
MH  - Glycation End Products, Advanced
MH  - Humans
MH  - Insulin Resistance/physiology
MH  - Mitogen-Activated Protein Kinases/antagonists & inhibitors/metabolism
MH  - Monocytes/cytology/*enzymology
MH  - Protein Kinase C/antagonists & inhibitors/metabolism
MH  - Serum Albumin/*pharmacology
MH  - Signal Transduction/*drug effects/physiology
MH  - Staurosporine/pharmacology
MH  - Superoxide Dismutase/pharmacology
MH  - Tetradecanoylphorbol Acetate/*pharmacology
MH  - Tumor Necrosis Factor-alpha/*metabolism
MH  - Glycated Serum Albumin
EDAT- 2001/05/23 10:00
MHDA- 2001/08/10 10:01
CRDT- 2001/05/23 10:00
PHST- 2001/05/23 10:00 [pubmed]
PHST- 2001/08/10 10:01 [medline]
PHST- 2001/05/23 10:00 [entrez]
AID - S0898-6568(01)00152-8 [pii]
AID - 10.1016/s0898-6568(01)00152-8 [doi]
PST - ppublish
SO  - Cell Signal. 2001 May;13(5):331-4. doi: 10.1016/s0898-6568(01)00152-8.