PMID- 11369984
OWN - NLM
STAT- MEDLINE
DCOM- 20010726
LR  - 20170926
IS  - 0364-2313 (Print)
IS  - 0364-2313 (Linking)
VI  - 25
IP  - 5
DP  - 2001 May
TI  - Determination of the immunoglobulin E postoperative variation as a measure of 
      surgical injury.
PG  - 585-91
AB  - The aim of this study was to ascertain postoperative changes in immunoglobulin E 
      (IgE) in patients undergoing different types of surgery and the possible 
      correlation with the duration and type of surgery. Evidence suggests that surgery 
      induces a predominant activation pattern through the T-helper-2 (Th2) cell 
      pathway, increasing interleukins (IL-4, IL-5, IL-10, IL-13), inhibiting Th1 cell 
      activation, and promoting B and Th2 cell activation. IgE production may indicate 
      predominant Th2 pathway activation and may be a more persistent and easily 
      measurable postoperative marker than IL-6 for measuring surgical trauma. 
      Altogether, 180 patients undergoing different types of surgery for nonneoplastic 
      and nonparasitic diseases were studied. All patients received the same type of 
      anesthesia. Before surgery and on the first (1PO) and 7th (7PO) postoperative 
      days we determined in peripheral blood the CD3, CD4, CD8, CD16, and CD19 cell 
      percentages; IL-1, IL-2, IL-4, IL-6, and tumor necrosis factor (TNF) levels; and 
      the IgA, IgG, IgM, total IgE, C3, C4, and CIC levels. On 1PO, all variables 
      decreased except IgE, IL-1, IL-2, IL-4, IL-6, CIC, and CD19. Only IgE, IL-6, and 
      CD19 increases showed a significantly statistical (ss) difference regarding 
      preoperative values (0.01, 0.05, 0.001, respectively). Relations between the IL-4 
      and IgE increases (p < 0.01) and between the IgG decrease and IgE increase (p < 
      0.001) were found. On 7PO, only IgE was increased (p < 0.001). The IgE increase 
      correlated with surgical trauma intensity (p < 0.05). We concluded that IgE 
      increases during the early postoperative period, correlating with surgical injury 
      intensity. The increase in the IgE level may be detected 24 hours after surgery 
      and during the first 7 postoperative days depending on the type of surgery.
FAU - Navarro-Zorraquino, M
AU  - Navarro-Zorraquino M
AD  - Department of Surgery, Hospital Clinico Universitario "Lozano Blesa," University 
      of Zaragoza, Domingo Miral s/n, 50009 Zaragoza, Spain. martana@posta.unizar.es
FAU - Lozano, R
AU  - Lozano R
FAU - Deus, J
AU  - Deus J
FAU - Pastor, C
AU  - Pastor C
FAU - Larrad, L
AU  - Larrad L
FAU - Tejero, E
AU  - Tejero E
FAU - Roman, J
AU  - Roman J
FAU - Palacios, M J
AU  - Palacios MJ
FAU - Torcal, J
AU  - Torcal J
FAU - Salinas, J C
AU  - Salinas JC
LA  - eng
PT  - Journal Article
PL  - United States
TA  - World J Surg
JT  - World journal of surgery
JID - 7704052
RN  - 0 (Antigens, CD)
RN  - 0 (Immunoglobulins)
RN  - 0 (Interleukins)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
CIN - World J Surg. 2002 Nov;26(11):1399-400; author reply 1400-1. PMID: 12447567
MH  - Adult
MH  - Antigens, CD/blood
MH  - *Biliary Tract Surgical Procedures
MH  - *Cardiovascular Surgical Procedures
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Immunoglobulins/blood
MH  - Interleukins/blood
MH  - Male
MH  - Middle Aged
MH  - Postoperative Period
MH  - *Thoracic Surgical Procedures
MH  - *Vascular Surgical Procedures
EDAT- 2001/05/23 10:00
MHDA- 2001/07/28 10:01
CRDT- 2001/05/23 10:00
PHST- 2001/05/23 10:00 [pubmed]
PHST- 2001/07/28 10:01 [medline]
PHST- 2001/05/23 10:00 [entrez]
AID - 10.1007/s002680020089 [doi]
PST - ppublish
SO  - World J Surg. 2001 May;25(5):585-91. doi: 10.1007/s002680020089.