PMID- 11376107
OWN - NLM
STAT- MEDLINE
DCOM- 20010816
LR  - 20211203
IS  - 0888-8809 (Print)
IS  - 0888-8809 (Linking)
VI  - 15
IP  - 6
DP  - 2001 Jun
TI  - Mammary gland involution is delayed by activated Akt in transgenic mice.
PG  - 867-81
AB  - Activation of the antiapoptotic protein kinase Akt is induced by a number of 
      growth factors that regulate mammary gland development. Akt is expressed during 
      mammary gland development, and expression decreases at the onset of involution. 
      To address Akt actions in mammary gland development, transgenic mice were 
      generated expressing constitutively active Akt in the mammary gland under the 
      control of the mouse mammary tumor virus (MMTV) promoter. Analysis of mammary 
      glands from these mice reveals a delay in both involution and the onset of 
      apoptosis. Expression of tissue inhibitor of metalloproteinase-1 (TIMP-1), an 
      inhibitor of matrix metalloproteinases (MMPs), is prolonged and increased in the 
      transgenic mice, suggesting that disruption of the MMP:TIMP ratio may contribute 
      to the delayed mammary gland involution observed in the transgenic mice.
FAU - Schwertfeger, K L
AU  - Schwertfeger KL
AD  - Program in Molecular Biology, University of Colorado Health Sciences Center, 4200 
      East Ninth Avenue, Denver, CO 80262, USA.
FAU - Richert, M M
AU  - Richert MM
FAU - Anderson, S M
AU  - Anderson SM
LA  - eng
GR  - CA-085736/CA/NCI NIH HHS/United States
GR  - CA-46934/CA/NCI NIH HHS/United States
GR  - DK-48845/DK/NIDDK NIH HHS/United States
GR  - DK-53858/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Mol Endocrinol
JT  - Molecular endocrinology (Baltimore, Md.)
JID - 8801431
RN  - 0 (Caseins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Milk Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (STAT3 Transcription Factor)
RN  - 0 (STAT5 Transcription Factor)
RN  - 0 (Stat3 protein, mouse)
RN  - 0 (Tissue Inhibitor of Metalloproteinase-1)
RN  - 0 (Trans-Activators)
RN  - 0 (whey acidic proteins)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Animals
MH  - *Apoptosis
MH  - Caseins/genetics/metabolism
MH  - DNA-Binding Proteins/genetics/metabolism
MH  - Female
MH  - Immunoblotting
MH  - Lactation/physiology
MH  - Mammary Glands, Animal/cytology/*physiology
MH  - Mammary Tumor Virus, Mouse/genetics/metabolism
MH  - Matrix Metalloproteinase 3/genetics/metabolism
MH  - Mice
MH  - Mice, Transgenic
MH  - Microscopy, Fluorescence
MH  - Milk Proteins/genetics/metabolism
MH  - Phosphorylation
MH  - Protein Serine-Threonine Kinases/*metabolism
MH  - Proto-Oncogene Proteins/genetics/*metabolism
MH  - Proto-Oncogene Proteins c-akt
MH  - STAT3 Transcription Factor
MH  - STAT5 Transcription Factor
MH  - Tissue Inhibitor of Metalloproteinase-1/genetics/metabolism
MH  - Trans-Activators/genetics/metabolism
EDAT- 2001/05/29 10:00
MHDA- 2001/08/17 10:01
CRDT- 2001/05/29 10:00
PHST- 2001/05/29 10:00 [pubmed]
PHST- 2001/08/17 10:01 [medline]
PHST- 2001/05/29 10:00 [entrez]
AID - 10.1210/mend.15.6.0663 [doi]
PST - ppublish
SO  - Mol Endocrinol. 2001 Jun;15(6):867-81. doi: 10.1210/mend.15.6.0663.