PMID- 11376865
OWN - NLM
STAT- MEDLINE
DCOM- 20010628
LR  - 20190819
IS  - 0300-483X (Print)
IS  - 0300-483X (Linking)
VI  - 163
IP  - 1
DP  - 2001 May 28
TI  - Preliminary assessment of the skin sensitizing activity of selected rodent 
      carcinogens using the local lymph node assay.
PG  - 63-9
AB  - It has been demonstrated previously that there exists an incomplete correlation 
      between the skin sensitizing potential of chemicals and their mutagenic 
      properties as judged by activity in the Salmonella mutation assay. More recently, 
      it has been proposed that there may exist a broader association between 
      carcinogenicity in rodents (including non-genotoxic carcinogenesis) and skin 
      sensitizing activity. To explore further these putative relationships we have 
      here examined the skin sensitizing potential of two non-genotoxic rodent 
      carcinogens which are generally considered not to represent a carcinogenic hazard 
      in humans (limonene and saccharin) and of three genotoxic rodent carcinogens 
      (vinylidene dichloride, ethyl acrylate and bisphenol A diglycidyl ether). For 
      this purpose we have used the local lymph node assay (LLNA), a method for the 
      identification and characterization of skin sensitizing chemicals that has 
      recently been recognized as a stand-alone method for hazard identification 
      purposes. Activity in the LLNA was compared with the results of Salmonella tests 
      conducted previously. This small series of investigations reveals that there 
      exists no general relationship between skin sensitizing potential and rodent 
      carcinogenicity. Furthermore, although a general correlation does exist between 
      mutagenic activity and skin sensitization, this association is not universal and 
      activity in the Salmonella mutation assay does not necessarily imply skin 
      sensitizing potential. Collectively these data suggest that it is inappropriate 
      currently to recommend the use of skin sensitization tests as an adjunct to 
      conventional approaches to the evaluation of potential carcinogenicity.
FAU - Warbrick, E V
AU  - Warbrick EV
AD  - Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, SK10 4TJ, 
      Cheshire, UK.
FAU - Dearman, R J
AU  - Dearman RJ
FAU - Ashby, J
AU  - Ashby J
FAU - Schmezer, P
AU  - Schmezer P
FAU - Kimber, I
AU  - Kimber I
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Toxicology
JT  - Toxicology
JID - 0361055
RN  - 0 (Acetates)
RN  - 0 (Benzhydryl Compounds)
RN  - 0 (Carcinogens)
RN  - 0 (Cyclohexenes)
RN  - 0 (Dichloroethylenes)
RN  - 0 (Epoxy Compounds)
RN  - 0 (Terpenes)
RN  - 21SK105J9D (vinylidene chloride)
RN  - 76845O8NMZ (ethyl acetate)
RN  - 9MC3I34447 (Limonene)
RN  - F3XRM1NX4H (2,2-bis(4-glycidyloxyphenyl)propane)
RN  - FST467XS7D (Saccharin)
SB  - IM
MH  - Acetates/toxicity
MH  - Animals
MH  - Benzhydryl Compounds
MH  - Carcinogenicity Tests/*methods
MH  - Carcinogens/*toxicity
MH  - Cyclohexenes
MH  - Dermatitis, Allergic Contact/*etiology/immunology
MH  - Dichloroethylenes/toxicity
MH  - Epoxy Compounds/toxicity
MH  - Female
MH  - Limonene
MH  - Local Lymph Node Assay
MH  - Mice
MH  - Mice, Inbred CBA
MH  - Saccharin/toxicity
MH  - Terpenes/toxicity
EDAT- 2001/05/30 10:00
MHDA- 2001/06/29 10:01
CRDT- 2001/05/30 10:00
PHST- 2001/05/30 10:00 [pubmed]
PHST- 2001/06/29 10:01 [medline]
PHST- 2001/05/30 10:00 [entrez]
AID - S0300483X01003808 [pii]
AID - 10.1016/s0300-483x(01)00380-8 [doi]
PST - ppublish
SO  - Toxicology. 2001 May 28;163(1):63-9. doi: 10.1016/s0300-483x(01)00380-8.