PMID- 11376903
OWN - NLM
STAT- MEDLINE
DCOM- 20010712
LR  - 20220310
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 305
IP  - 2
DP  - 2001 Jun 8
TI  - Patterns of retinal ganglion cell survival after brain-derived neurotrophic 
      factor administration in hypertensive eyes of rats.
PG  - 139-42
AB  - We investigated the effect of brain-derived neurotrophic factor (BDNF) on retinal 
      ganglion cell (RGC) survival after intraocular pressure (IOP) elevation at 
      various time intervals. In adult Wistar rats, RGCs were labeled with 5% 
      Fluorogold. Animals with 1.8-2.5-fold increase in IOP after cauterization of 
      three episcleral vessels, were divided into three BDNF groups and three vehicle 
      control groups, each receiving one, two or three injections. The RGC survival 
      percentage on RGCs of the first, second and third injections were 93.9% (n = 7), 
      91.3% (n = 7), 82.7% (n = 5), respectively in BDNF groups; 91.6% (n = 6), 84.1% 
      (n = 6) and 73.5% (n = 5), respectively in vehicle controls. The second and third 
      injections of BDNF showed statistically significant survival effects. These 
      findings demonstrated that BDNF has partial neuroprotection on RGCs in whole 
      retina and enhances RGC survival in moderately chronic hypertensive eyes.
FAU - Ko, M L
AU  - Ko ML
AD  - Department of Physiology, National Taiwan University, 1, Section 1, Jen-Ai Road, 
      10018, Taipei, Taiwan.
FAU - Hu, D N
AU  - Hu DN
FAU - Ritch, R
AU  - Ritch R
FAU - Sharma, S C
AU  - Sharma SC
FAU - Chen, C F
AU  - Chen CF
LA  - eng
GR  - EY 11295/EY/NEI NIH HHS/United States
GR  - NSC 89-2320-B002-171/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Recombinant Proteins)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*administration & dosage/pharmacology
MH  - Cell Survival/drug effects
MH  - Female
MH  - Glaucoma/pathology/*physiopathology
MH  - Humans
MH  - Injections
MH  - Intraocular Pressure/drug effects
MH  - Neuroprotective Agents/*administration & dosage/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Recombinant Proteins/administration & dosage/pharmacology
MH  - Retinal Ganglion Cells/*drug effects/*physiology
MH  - Vitreous Body
EDAT- 2001/05/30 10:00
MHDA- 2001/07/13 10:01
CRDT- 2001/05/30 10:00
PHST- 2001/05/30 10:00 [pubmed]
PHST- 2001/07/13 10:01 [medline]
PHST- 2001/05/30 10:00 [entrez]
AID - S0304394001018304 [pii]
AID - 10.1016/s0304-3940(01)01830-4 [doi]
PST - ppublish
SO  - Neurosci Lett. 2001 Jun 8;305(2):139-42. doi: 10.1016/s0304-3940(01)01830-4.