PMID- 113782
OWN - NLM
STAT- MEDLINE
DCOM- 19791121
LR  - 20171117
IS  - 0032-5473 (Print)
IS  - 0032-5473 (Linking)
VI  - 55 Suppl 2
DP  - 1979
TI  - HLA and insulin-dependent diabetes mellitus.
PG  - 8-13
AB  - As suggested from clinical data and on the basis of human leukocyte antigen (HLA) 
      data, insulin-dependent diabetes mellitus (IDDM) is a disease entity in itself 
      and is different from non-insulin-dependent diabetes and other types of diabetes 
      mellitus in aetiology and pathogenesis. HLA-B8 is associated with IDDM in all 
      Caucasian populations studied, irrespective of the age of onset of the disease. 
      HLA-B15 is associated with IDDM in populations of Northern European and British 
      origin, while B18 seems to replace B15 in Southern European populations. IDDM is 
      uncommon in populations where the HLA-B8 frequency is low, and in the Japanese 
      IDDM occurs in association with Bw22. The HLA-Dw3 and Dw4 association with IDDM 
      is stronger than that of the B alleles. Relative risks for B8 and B15 
      heterozygous and homozygous individuals are identical, i.e., no gene-dose effect 
      exists. The relative risk of B8/B15 carriers is double that of relative risks of 
      B8 and B15 alone, i.e., there are two IDDM-associated genes. The same applies to 
      Dw3/Dw4 carriers. In families the phenotype IDDM segregates with a certain 
      genotype, the diabetic proband's HLA haplotype. Only a small proportion of family 
      members carrying the 'diabetic haplotype' develop IDDM.
FAU - Nerup, J
AU  - Nerup J
FAU - Christy, M
AU  - Christy M
FAU - Kromann, H
AU  - Kromann H
FAU - Platz, P
AU  - Platz P
FAU - Ryder, L P
AU  - Ryder LP
FAU - Thomsen, M
AU  - Thomsen M
FAU - Svejgaard, A
AU  - Svejgaard A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Postgrad Med J
JT  - Postgraduate medical journal
JID - 0234135
RN  - 0 (HLA Antigens)
RN  - 0 (Insulin)
SB  - IM
MH  - Autoimmune Diseases/immunology
MH  - Diabetes Mellitus/drug therapy/genetics/*immunology
MH  - Gene Frequency
MH  - Genes, MHC Class II
MH  - Genetic Carrier Screening
MH  - HLA Antigens/*genetics
MH  - Humans
MH  - Insulin/therapeutic use
RF  - 33
EDAT- 1979/01/01 00:00
MHDA- 1979/01/01 00:01
CRDT- 1979/01/01 00:00
PHST- 1979/01/01 00:00 [pubmed]
PHST- 1979/01/01 00:01 [medline]
PHST- 1979/01/01 00:00 [entrez]
PST - ppublish
SO  - Postgrad Med J. 1979;55 Suppl 2:8-13.