PMID- 11378605
OWN - NLM
STAT- MEDLINE
DCOM- 20010614
LR  - 20220409
IS  - 0090-3493 (Print)
IS  - 0090-3493 (Linking)
VI  - 29
IP  - 5
DP  - 2001 May
TI  - Dehydroepiandrosterone, dehydroepiandrosterone-sulfate, and cortisol 
      concentrations in intensive care unit patients.
PG  - 965-70
AB  - STUDY OBJECTIVE: This purpose of this study was to determine whether severity of 
      illness, as defined by the intensive care unit (ICU) admission APACHE II (updated 
      Acute Physiology and Chronic Health Evaluation) score, is correlated with early 
      morning cortisol, dehydroepiandrosterone (DHEA), and/or 
      dehydroepiandrosterone-sulfate (DHEA-S) concentrations. DESIGN: Early morning 
      concentrations of DHEA, DHEA-S, and cortisol were determined within 24 hrs of 
      admission and compared with admission APACHE II scores. SETTING: Medical (MICU), 
      neurologic (NICU), and surgical (SICU) intensive care units of the University of 
      Pittsburgh Medical Center. PATIENTS: A total of 191 men and women ranging in age 
      from 16 to 93 yrs. All had been admitted to an ICU. MEASUREMENTS AND MAIN 
      RESULTS: Statistically significant correlations between APACHE II scores and 
      cortisol were observed for women in the MICU and SICU (r = .68, p = .0001; r = 
      .35 p = .017, respectively) and for men in the NICU (r = .55, p = .003) and the 
      SICU (r = .29, p = .036). The correlations between APACHE II scores and DHEA 
      concentration data were statistically significant for women in the MICU (r = .37, 
      p = .047) and SICU (r = .43, p = .002), as was the correlation between APACHE II 
      and DHEA-S concentrations among women in the SICU (r = .38, p = .008). Although 
      not statistically significant, a similar relationship was observed in the smaller 
      group of NICU women (r = .40, p = .099). Each correlation was essentially 
      unchanged when adjusted for age. CONCLUSION: These data show a positive 
      correlation between APACHE II and cortisol concentrations in all groups except 
      the MICU men. Also evident is the positive correlation between APACHE II scores 
      and DHEA and DHEA-S concentrations in women, but not in men.
FAU - Folan, M M
AU  - Folan MM
AD  - Department of Pharmaceutical Sciences, School of Pharmacy, University of 
      Pittsburgh, Pittsburgh, PA 15261, USA.
FAU - Stone, R A
AU  - Stone RA
FAU - Pittenger, A L
AU  - Pittenger AL
FAU - Stoffel, J A
AU  - Stoffel JA
FAU - Hess, M M
AU  - Hess MM
FAU - Kroboth, P D
AU  - Kroboth PD
LA  - eng
GR  - R01MH 55756/MH/NIMH NIH HHS/United States
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Crit Care Med
JT  - Critical care medicine
JID - 0355501
RN  - 0 (Adjuvants, Immunologic)
RN  - 459AG36T1B (Dehydroepiandrosterone)
RN  - 57B09Q7FJR (Dehydroepiandrosterone Sulfate)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - *APACHE
MH  - Adjuvants, Immunologic/blood
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Dehydroepiandrosterone/*blood
MH  - Dehydroepiandrosterone Sulfate/*blood
MH  - Female
MH  - Humans
MH  - Hydrocortisone/*blood
MH  - Intensive Care Units
MH  - Male
MH  - Middle Aged
MH  - Regression Analysis
MH  - Sex Distribution
EDAT- 2001/05/30 10:00
MHDA- 2001/06/15 10:01
CRDT- 2001/05/30 10:00
PHST- 2001/05/30 10:00 [pubmed]
PHST- 2001/06/15 10:01 [medline]
PHST- 2001/05/30 10:00 [entrez]
AID - 10.1097/00003246-200105000-00012 [doi]
PST - ppublish
SO  - Crit Care Med. 2001 May;29(5):965-70. doi: 10.1097/00003246-200105000-00012.