PMID- 11380412
OWN - NLM
STAT- MEDLINE
DCOM- 20010705
LR  - 20190705
IS  - 0007-1048 (Print)
IS  - 0007-1048 (Linking)
VI  - 113
IP  - 2
DP  - 2001 May
TI  - Molecular cytogenetic characterization of an acquired minute supernumerary marker 
      chromosome as the sole abnormality in a case clinically diagnosed as atypical 
      Philadelphia-negative chronic myelogenous leukaemia.
PG  - 435-8
AB  - A case of chronic myelogenous leukaemia (CML) in a 48-year-old man is reported. 
      To the best of our knowledge, this is the first report of a Philadelphia-negative 
      CML with an acquired small supernumerary marker chromosome (SMC) 11 as the sole 
      abnormality. The derivative chromosome 11 was studied in detail using molecular 
      cytogenetic methods; fluorescence in situ hybridization (FISH) using centromere- 
      and region-specific probes for chromosome 11, microdissection, micro-comparative 
      genomic hybridization (micro-CGH) and the recently developed multicolour banding 
      (MCB) technique. The acquired SMC was determined to be a ring chromosome that can 
      be described as r(11)(:p11.2-->q13.1:q14:).
FAU - Starke, H
AU  - Starke H
AD  - Institute of Human Genetics and Anthropology, Friedrich Schiller University, 
      Jena, Germany.
FAU - Raida, M
AU  - Raida M
FAU - Trifonov, V
AU  - Trifonov V
FAU - Clement, J H
AU  - Clement JH
FAU - Loncarevic, I F
AU  - Loncarevic IF
FAU - Heller, A
AU  - Heller A
FAU - Bleck, C
AU  - Bleck C
FAU - Nietzel, A
AU  - Nietzel A
FAU - Rubtsov, N
AU  - Rubtsov N
FAU - Claussen, U
AU  - Claussen U
FAU - Liehr, T
AU  - Liehr T
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Chromosome Aberrations/*genetics
MH  - Chromosome Disorders
MH  - *Chromosomes, Human, Pair 11
MH  - Genetic Markers
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative/*genetics
MH  - Male
MH  - Middle Aged
EDAT- 2001/05/31 10:00
MHDA- 2001/07/06 10:01
CRDT- 2001/05/31 10:00
PHST- 2001/05/31 10:00 [pubmed]
PHST- 2001/07/06 10:01 [medline]
PHST- 2001/05/31 10:00 [entrez]
AID - bjh2787 [pii]
AID - 10.1046/j.1365-2141.2001.02787.x [doi]
PST - ppublish
SO  - Br J Haematol. 2001 May;113(2):435-8. doi: 10.1046/j.1365-2141.2001.02787.x.