PMID- 11381507
OWN - NLM
STAT- MEDLINE
DCOM- 20011004
LR  - 20060803
IS  - 0941-1291 (Print)
IS  - 0941-1291 (Linking)
VI  - 31
IP  - 5
DP  - 2001
TI  - Thymic carcinoid in a patient with multiple endocrine neoplasia type 1: report of 
      a case.
PG  - 428-32
AB  - We report herein the rare case of a 33-year-old man found to have a multiple 
      endocrine neoplasia type 1 (MEN1)-associated carcinoid tumor in the thymus. A 
      chest roentgenogram demonstrated an asymptomatic anterior mediastinal mass, 7 cm 
      in diameter, and ultrasound-guided percutaneous Tru-Cut biopsy revealed a 
      carcinoid tumor of the thymus. An extended thymectomy was performed through a 
      median sternotomy and pathological examination confirmed the diagnosis of a 
      thymic carcinoid tumor, which was mainly encapsulated with locally invasive 
      growth into the pleura. Despite the absence of a family history of MEN1, he was 
      treated for two pancreatic islet cell tumors, hyperparathyroidism, an adrenal 
      tumor, and a retroperitoneal lipoma. MEN1 mutations were detected both in blood 
      samples and pancreatic tumor tissues. He is now well without any evidence of 
      tumor recurrence 27 months after the operation for the thymic carcinoid. MEN1 
      mutations were screened by direct nucleotide sequencing of all protein-coding 
      regions of exons 2-10 of the MEN1 gene. Heterozygous germline mutation was 
      detected in the blood sample analyses. Moreover, fresh-frozen pancreatic tumor 
      tissues showed a loss of heterozygosity in the MEN1 region.
FAU - Sugiura, H
AU  - Sugiura H
AD  - Second Department of Surgery, Hokkaido University Hospital, N-14, W-5, Sapporo 
      060-8648, Japan.
FAU - Morikawa, T
AU  - Morikawa T
FAU - Itoh, K
AU  - Itoh K
FAU - Ono, K
AU  - Ono K
FAU - Okushiba, S
AU  - Okushiba S
FAU - Kondo, S
AU  - Kondo S
FAU - Kato, H
AU  - Kato H
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Japan
TA  - Surg Today
JT  - Surgery today
JID - 9204360
RN  - 0 (DNA, Neoplasm)
SB  - IM
MH  - Adult
MH  - Carcinoid Tumor/*complications/pathology/surgery
MH  - DNA, Neoplasm/genetics
MH  - Germ-Line Mutation
MH  - Humans
MH  - Male
MH  - Multiple Endocrine Neoplasia Type 1/*complications/pathology/surgery
MH  - Neoplasm Invasiveness
MH  - *Thymectomy
MH  - Thymus Neoplasms/*complications/pathology/surgery
EDAT- 2001/05/31 10:00
MHDA- 2001/10/05 10:01
CRDT- 2001/05/31 10:00
PHST- 2001/05/31 10:00 [pubmed]
PHST- 2001/10/05 10:01 [medline]
PHST- 2001/05/31 10:00 [entrez]
AID - 10.1007/s005950170134 [pii]
AID - 10.1007/s005950170134 [doi]
PST - ppublish
SO  - Surg Today. 2001;31(5):428-32. doi: 10.1007/s005950170134.