PMID- 11382907
OWN - NLM
STAT- MEDLINE
DCOM- 20011025
LR  - 20071114
IS  - 1096-214X (Electronic)
IS  - 1096-214X (Linking)
VI  - 3
IP  - 3
DP  - 2000
TI  - Effect of age on sensory gating of the sleep state-dependent P1/P50 midlatency 
      auditory evoked potential.
PG  - 97-105
AB  - The P1/P50 midlatency auditory evoked potential is a sleep state-dependent 
      waveform present during waking and rapid eye movement (REM) sleep and absent 
      during slow-wave sleep. The P50 potential was studied in normal male and female 
      subjects of various ages including post-pubertal adolescents (12-19 yrs), young 
      adults (24-39 yrs), middle-aged adults (40-55 yrs) and older adults (55-78 yrs). 
      There were no statistically significant differences in the mean peak amplitude or 
      mean peak latency of the P50 potential between males and females or between age 
      groups. Using a paired stimulus paradigm, the degree of sensory gating of the P50 
      potential was tested at three different interstimulus intervals (ISIs), 250, 500 
      and 1000 msec. There were no statistically significant differences in the sensory 
      gating of the P50 potential between males and females. However, there was a 
      significant decrease in sensory gating of the P50 potential in the adolescent 
      group compared to each of the other age groups at the 250 msec ISI, but not at 
      the 500 or 1000 msec ISI. These results suggest the presence of decreased sensory 
      gating in normal adolescents compared to normal, older age groups.
FAU - Rasco, L
AU  - Rasco L
AD  - Department of Anatomy, University of Arkansas for Medical Sciences, Little Rock, 
      AR, USA.
FAU - Skinner, R D
AU  - Skinner RD
FAU - Garcia-Rill, E
AU  - Garcia-Rill E
LA  - eng
GR  - NS20246/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Sleep Res Online
JT  - Sleep research online : SRO
JID - 100901064
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Analysis of Variance
MH  - Auditory Perception/*physiology
MH  - Auditory Threshold
MH  - Child
MH  - Evoked Potentials, Auditory/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Sex Factors
MH  - Sleep Stages/*physiology
EDAT- 2001/05/31 10:00
MHDA- 2001/10/26 10:01
CRDT- 2001/05/31 10:00
PHST- 2001/05/31 10:00 [pubmed]
PHST- 2001/10/26 10:01 [medline]
PHST- 2001/05/31 10:00 [entrez]
PST - ppublish
SO  - Sleep Res Online. 2000;3(3):97-105.