PMID- 11384049
OWN - NLM
STAT- MEDLINE
DCOM- 20011018
LR  - 20131121
IS  - 0022-0302 (Print)
IS  - 0022-0302 (Linking)
VI  - 84
IP  - 5
DP  - 2001 May
TI  - Effect of chromium supplementation on production and metabolic parameters in 
      periparturient dairy cows.
PG  - 1218-30
AB  - The effect of supplemental chromium as chromium-methionine (Cr-Met) on production 
      and metabolic parameters was investigated in 48 cows from 28 d before expected 
      calving date through 28 d of lactation. Average body weight (BW) was 730 +/- 61 
      kg before treatment. Treatments were supplementation of 0, 0.03, 0.06, and 0.12 
      mg of Cr as Cr-Met/kg of BW(0.75). Dry matter intake increased linearly and 
      quadratically during the prepartum and postpartum periods, respectively, and body 
      condition score loss decreased linearly during the postpartum period with 
      increasing Cr-Met. Increasing Cr-Met supplementation caused quadratic increases 
      in milk, fat, and lactose yields. Treatments did not affect concentrations of 
      blood metabolites and liver triglyceride. Serum insulin concentration and molar 
      ratio of insulin to glucose for cows receiving Cr-Met were lower than for cows 
      not receiving Cr-Met, but they increased quadratically with increasing Cr-Met. 
      Glucose tolerance tests (GTT) were conducted on d 10 prepartum and d 28 
      postpartum. Chromium-methionine supplementation attenuated insulin sensitivity 
      prepartum and enhanced glucose tolerance postpartum, but not prepartum. Basal 
      insulin concentrations for cows receiving Cr-Met were higher than for cows not 
      receiving Cr-Met during the prepartum GTT. During the postpartum GTT, peak 
      glucose concentration and clearance rate decreased and half-life (t(1/2)) and 
      time to reach basal concentration (T) were prolonged quadratically by increasing 
      Cr-Met. Additionally, peak insulin concentration, area under the curve, and molar 
      ratio of insulin to glucose were higher for cows not receiving Cr-Met than for 
      cows receiving Cr-Met and t(1/2) and T were shortened quadratically by increasing 
      Cr-Met.
FAU - Hayirli, A
AU  - Hayirli A
AD  - Department of Dairy Science, University of Wisconsin, Madison 53706-1284, USA.
FAU - Bremmer, D R
AU  - Bremmer DR
FAU - Bertics, S J
AU  - Bertics SJ
FAU - Socha, M T
AU  - Socha MT
FAU - Grummer, R R
AU  - Grummer RR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Dairy Sci
JT  - Journal of dairy science
JID - 2985126R
RN  - 0 (Amino Acids)
RN  - 0 (Nicotinic Acids)
RN  - 0 (glucose tolerance factor)
RN  - 0R0008Q3JB (Chromium)
SB  - IM
MH  - Amino Acids
MH  - Animals
MH  - Area Under Curve
MH  - Body Composition/drug effects
MH  - Body Weight
MH  - Cattle/*physiology
MH  - Chromium/*administration & dosage/*metabolism/pharmacology
MH  - Dietary Supplements
MH  - Dose-Response Relationship, Drug
MH  - Energy Metabolism/*drug effects
MH  - Female
MH  - Glucose Tolerance Test/veterinary
MH  - Lactation/*physiology
MH  - Milk/*chemistry
MH  - Nicotinic Acids
MH  - Postpartum Period/*drug effects/metabolism
MH  - Pregnancy
EDAT- 2001/06/01 10:00
MHDA- 2001/10/19 10:01
CRDT- 2001/06/01 10:00
PHST- 2001/06/01 10:00 [pubmed]
PHST- 2001/10/19 10:01 [medline]
PHST- 2001/06/01 10:00 [entrez]
AID - S0022-0302(01)74583-3 [pii]
AID - 10.3168/jds.S0022-0302(01)74583-3 [doi]
PST - ppublish
SO  - J Dairy Sci. 2001 May;84(5):1218-30. doi: 10.3168/jds.S0022-0302(01)74583-3.