PMID- 11384209
OWN - NLM
STAT- MEDLINE
DCOM- 20010621
LR  - 20161124
IS  - 0041-008X (Print)
IS  - 0041-008X (Linking)
VI  - 173
IP  - 2
DP  - 2001 Jun 1
TI  - Disposition of polychlorinated dibenzo-p-dioxins, dibenzofurans, and non-ortho 
      polychlorinated biphenyls in pregnant long evans rats and the transfer to 
      offspring.
PG  - 65-88
AB  - Pharmacokinetic properties of polychlorinated dibenzo-p-dioxins, dibenzofurans 
      (PCDFs), and non-ortho biphenyls (PCBs) play a critical role in their relative 
      toxicity. The present study examined the transfer of these chemicals to offspring 
      and placenta. Pregnant Long Evans rats received 0.0 (control), 0.05, 0.2, 0.8, 
      and 1.0 microg/kg of dioxin toxic equivalence (TEQ) by oral gavage on the 15th 
      gestational day (GD 15), using a dosing mixture that contained 
      2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 2,3,7,8-tetrachlorodibenzofuran 
      (TCDF), 1,2,3,7,8-pentachlorodibenzo-p-dioxin (PeCDD), 
      1,2,3,7,8-pentachlorodibenzofuran (1-PeCDF), 2,3,4,7,8-pentachlorodibenzofuran 
      (4-PeCDF), octachlorodibenzofuran (OCDF), 3,3',4,4'-tetrachlorobiphenyl (PCB 77), 
      3,3',4,4',5-pentachlorobiphenyl (PCB 126), and 3,3',4,4',5,5'-hexachlorobiphenyl 
      (PCB 169) in ratios approximating that in food. Rats were euthanized on GD 16, GD 
      21, and postnatal day 4 (PND 4). The chemical concentrations in fetus, pup, 
      placenta, and maternal liver, serum, and adipose tissue were determined using gas 
      chromatography/high-resolution mass spectrometry. A dose-dependent increase in 
      hepatic sequestration was seen with TCDD, PeCDD, 4-PeCDF, OCDF, PCB 126, and PCB 
      169, and the transfer to offspring was reduced at higher doses. 4-PeCDF, PeCDD 
      and PCB 126 showed higher liver affinity than TCDD. TCDF, 1-PeCDF, and PCB 77 
      were metabolized rapidly. On GD 16, TCDD and the three PCBs reached equilibration 
      between the fetus and placenta, but this did not occur with PeCDD and 4-PeCDF 
      until GD 21, according to the lipid-based concentrations. Offspring compartments 
      received more of the dosed compounds lactationally than transplacentally (7-28% 
      versus 0.5-3%). The behavior of each congener was dose-dependent; therefore, 
      extrapolation of high-dose experimental data should be used with caution.
CI  - Copyright 2001 Academic Press.
FAU - Chen, C Y
AU  - Chen CY
AD  - Department of Environmental Sciences and Engineering, University of North 
      Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7400, USA.
FAU - Hamm, J T
AU  - Hamm JT
FAU - Hass, J R
AU  - Hass JR
FAU - Birnbaum, L S
AU  - Birnbaum LS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Toxicol Appl Pharmacol
JT  - Toxicology and applied pharmacology
JID - 0416575
RN  - 0 (Benzofurans)
RN  - 0 (Polychlorinated Dibenzodioxins)
RN  - 0 (Polymers)
RN  - 0 (polychlorodibenzofuran)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adipose Tissue/metabolism
MH  - Animals
MH  - Benzofurans/*pharmacokinetics/toxicity
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Fetus/metabolism
MH  - Liver/metabolism
MH  - *Maternal-Fetal Exchange
MH  - Placenta/metabolism
MH  - Polychlorinated Biphenyls/*pharmacokinetics/toxicity
MH  - Polychlorinated Dibenzodioxins/*analogs & derivatives/*pharmacokinetics/toxicity
MH  - Polymers/*pharmacokinetics/toxicity
MH  - Pregnancy
MH  - Pregnancy, Animal/*metabolism
MH  - Rats
MH  - Rats, Long-Evans
MH  - Tissue Distribution
EDAT- 2001/06/01 10:00
MHDA- 2001/06/22 10:01
CRDT- 2001/06/01 10:00
PHST- 2001/06/01 10:00 [pubmed]
PHST- 2001/06/22 10:01 [medline]
PHST- 2001/06/01 10:00 [entrez]
AID - S0041-008X(01)99143-4 [pii]
AID - 10.1006/taap.2001.9143 [doi]
PST - ppublish
SO  - Toxicol Appl Pharmacol. 2001 Jun 1;173(2):65-88. doi: 10.1006/taap.2001.9143.