PMID- 11388147
OWN - NLM
STAT- MEDLINE
DCOM- 20010614
LR  - 20161209
IS  - 0755-4982 (Print)
IS  - 0755-4982 (Linking)
VI  - 30
IP  - 16
DP  - 2001 Apr 28
TI  - [Determination by flow cytometry of reference values of erythrocyte parameters in 
      aged subjects].
PG  - 779-84
AB  - OBJECTIVES: Normal values for hemoglobin and hematocrit have been established for 
      healthy young adults, but it is unknown whether age-related decline in 
      hematological values occurs in the elderly. We compared normal values of 
      hematological parameters in healthy adults and healthy persons aged 65 years and 
      over using flow cytometry. SUBJECTS AND METHODS: Erythrocyte and reticulocyte 
      parameters were determined in 585 subjects (294 men and 206 women aged 26 to 64 
      years, and 37 men and 48 women aged 65 years and over), living independently and 
      without medication, symptom and disease, using Technicon H1 (Bayer) and R2000 
      (Roche) analyzers. Serum erythropoietin levels, red cell folate and creatinine 
      clearance were determined in subjects aged 65 years and over. RESULTS: 
      Irrespective of subject age, hemoglobin (Hb), hematocrit (Hct), red blood cell 
      count (RBC), mean cell volume (MCV), mean corpuscular hemoglobin (MCH) and mean 
      corpuscular hemoglobin concentration (MCHC) were higher in males than in females, 
      but sex-related differences tended to decrease with aging. In males, there was a 
      trend toward lower Hb and Hct with aging, due to an increase in RBC, MCV and MCH. 
      In females, Hb and Hct (p < 0.05) increased with aging, due to a trend toward 
      higher values of RBC, MCV and MCH. Red blood cell distribution width and 
      hemoglobin distribution width were not modified by aging. Despite these 
      age-related changes in erythrocyte parameters, values for anemia defined in 
      adults appear appropriate for geriatric subjects (Hb < 130 g/l in males and Hb < 
      120 g/l in females). Reticulocyte count and creatinine clearance decreased in men 
      and women aged 65 years and over (p < 0.05), whereas erythropoietin levels and 
      red cell folate were not influenced by aging. CONCLUSION: Normal erythrocyte 
      values defined in adults are appropriate for evaluating hematological test 
      results in older individuals. The decrease in reticulocyte count observed in men 
      and women aged 65 years and over does not appear to be linked to a decrease in 
      erythropoietin production with aging.
FAU - Blain, H
AU  - Blain H
AD  - Centre de Gerontologie clinique, CHU de Montpellier. h-blain@chu-montpellier.fr
FAU - Lerouge, S
AU  - Lerouge S
FAU - Blain, A
AU  - Blain A
FAU - Lacomski, D
AU  - Lacomski D
FAU - Virion, J M
AU  - Virion JM
FAU - Humbert, J C
AU  - Humbert JC
FAU - Jeandel, C
AU  - Jeandel C
LA  - fre
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
TT  - Determination par cytometrie de flux des valeurs de reference de la population 
      erythrocytaire chez le sujet age.
PL  - France
TA  - Presse Med
JT  - Presse medicale (Paris, France : 1983)
JID - 8302490
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - *Aged
MH  - *Erythrocyte Indices
MH  - Female
MH  - *Flow Cytometry
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Reference Values
MH  - Sex Factors
EDAT- 2001/06/05 10:00
MHDA- 2001/06/15 10:01
CRDT- 2001/06/05 10:00
PHST- 2001/06/05 10:00 [pubmed]
PHST- 2001/06/15 10:01 [medline]
PHST- 2001/06/05 10:00 [entrez]
PST - ppublish
SO  - Presse Med. 2001 Apr 28;30(16):779-84.