PMID- 11389170
OWN - NLM
STAT- MEDLINE
DCOM- 20010712
LR  - 20190630
IS  - 0022-3042 (Print)
IS  - 0022-3042 (Linking)
VI  - 77
IP  - 5
DP  - 2001 Jun
TI  - Long-term potentiation in the dentate gyrus of the rat hippocampus is accompanied 
      by brain-derived neurotrophic factor-induced activation of TrkB.
PG  - 1198-207
AB  - A role for neurotrophic factors, in particular brain-derived neurotrophic factor 
      (BDNF), in modulating synaptic plasticity in the adult brain has been described 
      in recent years by several laboratories. A great deal of emphasis has been placed 
      on establishing its precise role in the expression of long-term potentiation 
      (LTP) in the hippocampus. Here we attempt to address this question by 
      investigating, first, its release following induction of LTP in perforant 
      path-granule cell synapses and, second, the signalling events which follow 
      activation of the BDNF receptor, TrkB, in the presynaptic terminal. We report 
      that BDNF release is increased from slices of dentate gyrus following tetanic 
      stimulation of the perforant path and that TrkB activation is increased in 
      synaptosomes prepared from tetanized dentate gyrus. These changes are accompanied 
      by increased activation of one member of the family of mitogen-activated protein 
      kinases, extracellular signal-regulated kinase (ERK) and the data indicate that 
      these events play a role in modulating release of glutamate from perforant 
      path-granule cell synapses, because the Trk inhibitor K252a and the ERK 
      inhibitor, UO126, both inhibited the BDNF-induced enhancement of release. We 
      propose that the increase in phosphorylation of the transcription factor cAMP 
      response element binding protein and in protein synthesis might underlie the more 
      persistent components of LTP in dentate gyrus.
FAU - Gooney, M
AU  - Gooney M
AD  - Department of Physiology, Trinity College Institute of Neuroscience, Trinity 
      College, Dublin, Ireland.
FAU - Lynch, M A
AU  - Lynch MA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Neurochem
JT  - Journal of neurochemistry
JID - 2985190R
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (Nerve Tissue Proteins)
RN  - 3KX376GY7L (Glutamic Acid)
RN  - AE28F7PNPL (Methionine)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Biotransformation/*physiology
MH  - Brain-Derived Neurotrophic Factor/*physiology
MH  - Cyclic AMP Response Element-Binding Protein/metabolism
MH  - Dentate Gyrus/*physiology
MH  - Glutamic Acid/metabolism
MH  - Long-Term Potentiation/*physiology
MH  - Male
MH  - Methionine/metabolism
MH  - Nerve Tissue Proteins/biosynthesis
MH  - Phosphorylation
MH  - Rats
MH  - Rats, Wistar
MH  - Receptor, trkB/*physiology
MH  - Synaptosomes/metabolism
EDAT- 2001/06/05 10:00
MHDA- 2001/07/13 10:01
CRDT- 2001/06/05 10:00
PHST- 2001/06/05 10:00 [pubmed]
PHST- 2001/07/13 10:01 [medline]
PHST- 2001/06/05 10:00 [entrez]
AID - 10.1046/j.1471-4159.2001.00334.x [doi]
PST - ppublish
SO  - J Neurochem. 2001 Jun;77(5):1198-207. doi: 10.1046/j.1471-4159.2001.00334.x.